Protein Information

Cytoscape View

UniProt AC / UniProt ID P99999 / CYC_HUMAN
Protein Name Cytochrome c
Gene Name Name: CYCS
Organism Homo sapiens (Human)

PRO ID PR:P99999
DAG View
PRO Name cytochrome c (human)
Definition A cytochrome c, somatic that is encoded in the genome of human.
Short Label hCYCS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P99999 (CYCS) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
G2 Acetylation UniProt 13933734
K9 Acetylation PhosphoSitePlus
K28 Sumoylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
T29 Phosphorylation HPRD   PhosphoSitePlus 20068231
K40 Ubiquitination PhosphoSitePlus
T41 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K100 Methylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K101 Methylation PhosphoSitePlus

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S46 P99999 (CYCS) unknown eFIP 19521340
Phosphorylation P04792 (HSPB1) S78 P99999 (CYCS) unknown eFIP 22974980

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P99999-1 (hCYCS/iso:1) Interaction PR:O14727-3 (hAPAF1/iso:3) PRO 9267021

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
G2 R2 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
G2 S2 Biomuta DOID:363 / uterine cancer [ tcga ]
K9 N9 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T29 N29 Biomuta DOID:3571 / liver cancer [ icgc ]
S48 P48 Biomuta DOID:363 / uterine cancer [ tcga ]
K54 M54 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y68 H68 Biomuta DOID:9256 / colorectal cancer [ icgc ]