Protein Information

Cytoscape View

UniProt AC / UniProt ID P98170 / XIAP_HUMAN
Protein Name E3 ubiquitin-protein ligase XIAP
Gene Name Name: XIAP
Organism Homo sapiens (Human)

PRO ID PR:P98170
DAG View
PRO Name E3 ubiquitin-protein ligase XIAP (human)
Definition A baculoviral IAP repeat-containing protein 4 that is encoded in the genome of human.
Short Label hXIAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P98170 (XIAP) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S5 Phosphorylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
C12 S-Nitrosylation dbSNO 22178444, 19273858
K19 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S40 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 20068231, 27927753
S45 Phosphorylation PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
S87 Phosphorylation P31751 (AKT2) , P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17537996, 14645242, 24173770, ...21707856, 24176845, 31842909, 25686839, 26314849, 30867140, 31493422, 21559296, 32050753, 32462369, 31635307, 28977846
C90 S-Nitrosylation dbSNO 22178444, 19273858
K116 Ubiquitination PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
R131 Methylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
T180 Phosphorylation PhosphoSitePlus   RLIMS-P 29678905, 27927753
K208 Ubiquitination PhosphoSitePlus
C213 S-Nitrosylation dbSNO 22178444, 19273858
S218 Phosphorylation PhosphoSitePlus
R248 Methylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
C300 S-Nitrosylation dbSNO 22178444, 19273858
C303 S-Nitrosylation dbSNO 22178444, 19273858
K311 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus   UniProt 12747801
C327 S-Nitrosylation dbSNO 22178444, 19273858
K328 Ubiquitination PhosphoSitePlus   UniProt 12747801
K334 Ubiquitination PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
C351 S-Nitrosylation dbSNO 22178444, 19273858
T355 Phosphorylation HPRD 20068231
T356 Phosphorylation HPRD 20068231
K358 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
K405 Sumoylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
S430 Phosphorylation Q14164 (IKBKE) PhosphoSitePlus   RLIMS-P 22072751
K433 Ubiquitination PhosphoSitePlus
S436 Phosphorylation HPRD   PhosphoSitePlus 20068231
T437 Phosphorylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
T470 Phosphorylation HPRD 18452278
K480 Ubiquitination PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
T489 Phosphorylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049706 (hXIAP/UbiqLys+) ub PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NR28 (DIABLO) S67 P98170 (XIAP) increased_association eFIP 24038446

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q9NR28-1 (hDIABLO/iso:1) Interaction PR:P98170 (hXIAP) PRO 12660240

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K10 N10 Biomuta DOID:363 / uterine cancer [ tcga ]
C12 Y12 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T32 N32 Biomuta DOID:363 / uterine cancer [ tcga ]
C90 Y90 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C90 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K116 R116 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y120 N120 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R131 M131 Biomuta DOID:3070 / malignant glioma [ tcga ]
K168 N168 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
C303 Y303 Biomuta DOID:9256 / colorectal cancer [ icgc ]
C303 F303 Biomuta DOID:3571 / liver cancer [ icgc ]
C327 R327 Biomuta DOID:3070 / malignant glioma [ tcga ]
S400 Y400 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S402 I402 Biomuta DOID:3571 / liver cancer [ icgc ]
T437 I437 Biomuta DOID:1324 / lung cancer [ cosmic ]