iPTMnet Report for P98161 (PKD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P98161 / PKD1_HUMAN
Protein Name Polycystin-1 precursor
Gene Name Name: PKD1
Organism Homo sapiens (Human)

PRO ID PR:P98161
DAG View
PRO Name polycystin-1 (human)
Definition A polycystin-1 that is encoded in the genome of human.
Short Label hPKD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P98161 (PKD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T410 Phosphorylation RLIMS-P 24153433
C419 Methylation IEDB 31844290
S744 Phosphorylation RLIMS-P 25517939, 23028574, 31591827, ...28228588
S748 Phosphorylation RLIMS-P 25517939, 23028574, 31591827, ...28228588
S843 Phosphorylation PhosphoSitePlus
T856 Phosphorylation PhosphoSitePlus
T858 Phosphorylation PhosphoSitePlus
S916 Phosphorylation PhosphoSitePlus   RLIMS-P 30419840, 28228588, 23129748, ...20444281, 23028574, 25517939, 24740233, 31591827, 16651260, 30101477, 21998636
S1108 Phosphorylation PhosphoSitePlus
S1684 Phosphorylation PhosphoSitePlus
T1692 Phosphorylation PhosphoSitePlus
T1861 Phosphorylation PhosphoSitePlus
S1949 Phosphorylation PhosphoSitePlus
Y2004 Phosphorylation PhosphoSitePlus
R2089 Methylation PhosphoSitePlus
R2109 Methylation PhosphoSitePlus
S2164 Phosphorylation PhosphoSitePlus
Y2168 Phosphorylation PhosphoSitePlus
S2320 Phosphorylation PhosphoSitePlus
S2321 Phosphorylation PhosphoSitePlus
T2324 Phosphorylation PhosphoSitePlus
T2414 Phosphorylation PhosphoSitePlus
T2420 Phosphorylation PhosphoSitePlus
S2426 Phosphorylation PhosphoSitePlus
C2460 Methylation IEDB 31844290
T2488 Phosphorylation PhosphoSitePlus
T2489 Phosphorylation PhosphoSitePlus
Y3143 Phosphorylation PhosphoSitePlus
S3398 Phosphorylation PhosphoSitePlus
T3417 Phosphorylation PhosphoSitePlus
S3419 Phosphorylation PhosphoSitePlus
S4166 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 17980165
S4166 Phosphorylation P51817 (PRKX) neXtProt   PhosphoSitePlus   Signor 17980165
S4169 Phosphorylation PhosphoSitePlus
S4198 Phosphorylation PhosphoSitePlus
S4200 Phosphorylation PhosphoSitePlus
T4206 Phosphorylation PhosphoSitePlus
Y4237 Phosphorylation PhosphoSitePlus   RLIMS-P 21126580, 10362514
Y4237 Phosphorylation P12931 (SRC) PhosphoSitePlus 21126580, 10362514
S4251 Phosphorylation PhosphoSitePlus
S4252 Phosphorylation PhosphoSitePlus 10362514
S4252 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 10362514
S4263 Phosphorylation PhosphoSitePlus
T4285 Phosphorylation PhosphoSitePlus
S4288 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2320 Phosphorylation HPRD 20166139
S2321 Phosphorylation HPRD 20166139
T2324 Phosphorylation HPRD 20166139
S4288 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S2320 Phosphorylation HPRD 20166139
S2321 Phosphorylation HPRD 20166139
T2324 Phosphorylation HPRD 20166139
S4287 Phosphorylation HPRD 17081983


P98161 (PKD1) as PTM Enzyme



Substrate Site Score Source PMID
P04792 (HSPB1) S82 phospho.ELM 15728188
Q13671 (RIN1) S351 phospho.ELM 11784866
Q15139 (PRKD1) S205 phospho.ELM 10867018
Q15139 (PRKD1) S910 phospho.ELM 10473617, 16563698, 14607845
Q8WUI4 (HDAC7) S155 phospho.ELM 18509061, 18617643, 15623513
Q96A00 (PPP1R14A) T38 phospho.ELM 15003508
Q9ULH0 (KIDINS220) S918 neXtProt 10998417


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P98161 (PKD1) S916 P29475 (NOS1) unknown eFIP 24740233


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S1108 C1108 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1108 F1108 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1861 I1861 Biomuta DOID:1324 / lung cancer [ cosmic ]
T3417 M3417 Biomuta DOID:10534 / stomach cancer [ cosmic ]