Protein Information

Cytoscape View


UniProt AC / UniProt ID P98160 / PGBM_HUMAN
Protein Name Basement membrane-specific heparan sulfate proteoglycan core protein precursor
Gene Name Name: HSPG2
Organism Homo sapiens (Human)

PRO ID PR:P98160
DAG View
PRO Name basement membrane-specific heparan sulfate proteoglycan core protein (human)
Definition A basement membrane-specific heparan sulfate proteoglycan core protein that is encoded in the genome of human.
Short Label hHSPG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P98160 (HSPG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T42 O-Glycosylation UniProt 22171320
S105 Phosphorylation PhosphoSitePlus
T269 O-Glycosylation PhosphoSitePlus
S279 O-Glycosylation PhosphoSitePlus
S472 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y477 Phosphorylation HPRD   PhosphoSitePlus 18452278
T478 Phosphorylation HPRD   PhosphoSitePlus 18452278
N554 N-Glycosylation UniProt 19159218
T556 Phosphorylation PhosphoSitePlus
T563 Phosphorylation PhosphoSitePlus
Y616 Phosphorylation PhosphoSitePlus
Y620 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
T887 Phosphorylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
S914 O-Glycosylation PhosphoSitePlus
T915 O-Glycosylation PhosphoSitePlus
K1001 Ubiquitination PhosphoSitePlus
S1345 Phosphorylation PhosphoSitePlus
T1346 Phosphorylation PhosphoSitePlus
N1755 N-Glycosylation UniProt 16335952, 19159218
T1790 Phosphorylation PhosphoSitePlus
T1794 Phosphorylation PhosphoSitePlus
S1799 Phosphorylation PhosphoSitePlus
Y1802 Phosphorylation PhosphoSitePlus
T1816 Phosphorylation PhosphoSitePlus
T2005 Phosphorylation PhosphoSitePlus
Y2023 Phosphorylation PhosphoSitePlus
S2057 Phosphorylation PhosphoSitePlus
S2061 Phosphorylation PhosphoSitePlus
T2063 Phosphorylation PhosphoSitePlus
S2112 Phosphorylation PhosphoSitePlus
N2121 N-Glycosylation UniProt 12754519
T2138 O-Glycosylation PhosphoSitePlus
S2140 O-Glycosylation PhosphoSitePlus
T2145 O-Glycosylation PhosphoSitePlus
S2150 O-Glycosylation PhosphoSitePlus
T2151 O-Glycosylation PhosphoSitePlus
T2151 Phosphorylation PhosphoSitePlus
S2191 Phosphorylation PhosphoSitePlus
S2284 Phosphorylation PhosphoSitePlus
S2398 Phosphorylation PhosphoSitePlus
S2402 Phosphorylation PhosphoSitePlus
S2476 Phosphorylation PhosphoSitePlus
S2486 Phosphorylation PhosphoSitePlus
S2529 O-Glycosylation PhosphoSitePlus
S2691 Phosphorylation PhosphoSitePlus
T2843 Phosphorylation HPRD   PhosphoSitePlus 20068231
S2964 Phosphorylation PhosphoSitePlus
S2986 Phosphorylation PhosphoSitePlus
S3040 Phosphorylation PhosphoSitePlus
N3072 N-Glycosylation UniProt 19159218
S3151 Phosphorylation PhosphoSitePlus
T3152 O-Glycosylation PhosphoSitePlus
T3262 Phosphorylation PhosphoSitePlus
S3412 O-Glycosylation PhosphoSitePlus
S3488 Phosphorylation PhosphoSitePlus
S3630 Phosphorylation PhosphoSitePlus
S3712 Phosphorylation PhosphoSitePlus
T3714 Phosphorylation PhosphoSitePlus
T3767 Phosphorylation PhosphoSitePlus
N3780 N-Glycosylation UniProt 19159218
T3782 Phosphorylation PhosphoSitePlus
S3783 Phosphorylation PhosphoSitePlus
N3836 N-Glycosylation UniProt 19159218
N4068 N-Glycosylation UniProt 19159218
S4306 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S279 F279 Biomuta DOID:1909 / melanoma [ tcga ]
T478 I478 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T563 M563 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic ]
S888 F888 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T2005 I2005 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T2138 S2138 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S2140 F2140 Biomuta DOID:363 / uterine cancer [ tcga ]
S2150 I2150 Biomuta DOID:363 / uterine cancer [ tcga ]
S2398 P2398 Biomuta DOID:4159 / skin cancer [ icgc ]
S2486 L2486 Biomuta DOID:363 / uterine cancer [ tcga ]
T3152 A3152 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S3412 R3412 Biomuta DOID:3070 / malignant glioma [ tcga ]
S3630 * Biomuta DOID:3571 / liver cancer [ icgc ]
T3782 I3782 Biomuta DOID:1909 / melanoma [ tcga ]
S3783 F3783 Biomuta DOID:10534 / stomach cancer [ tcga ]