iPTMnet Report for P98160 (HSPG2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P98160 / PGBM_HUMAN
Protein Name Basement membrane-specific heparan sulfate proteoglycan core protein precursor
Gene Name Name: HSPG2
Organism Homo sapiens (Human)

PRO ID PR:P98160
DAG View
PRO Name basement membrane-specific heparan sulfate proteoglycan core protein (human)
Definition A basement membrane-specific heparan sulfate proteoglycan core protein that is encoded in the genome of human.
Short Label hHSPG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P98160 (HSPG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T40 O-Glycosylation GlyGen 30237853
T42 O-Glycosylation GlyGen   UniProt 25813380, 22171320
T49 O-Glycosylation GlyGen 25813380
Y52 O-Glycosylation GlyGen 25813380
N89 N-Glycosylation GlyGen 23090970, 29741879
S105 Phosphorylation PhosphoSitePlus
N210 N-Glycosylation GlyGen 23090970, 24190977
T251 O-Glycosylation GlyGen 30459171
T260 O-Glycosylation GlyGen 30459171, 25813380
T261 O-Glycosylation GlyGen 25813380
T269 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S279 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T361 O-Glycosylation GlyGen 30459171
S472 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y477 Phosphorylation HPRD   PhosphoSitePlus 18452278
T478 Phosphorylation HPRD   PhosphoSitePlus 18452278
N554 N-Glycosylation GlyGen   UniProt 29741879, 19159218
T556 Phosphorylation PhosphoSitePlus
T563 O-Glycosylation GlyGen 30459171
T563 Phosphorylation PhosphoSitePlus
Y616 Phosphorylation PhosphoSitePlus
Y620 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
T887 Phosphorylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
S914 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T915 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T972 O-Glycosylation GlyGen 30459171
K1001 Ubiquitination PhosphoSitePlus
T1145 O-Glycosylation GlyGen 30459171
T1147 O-Glycosylation GlyGen 30459171
S1345 Phosphorylation PhosphoSitePlus
T1346 Phosphorylation PhosphoSitePlus
N1755 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 19159218, ...24190977
T1790 Phosphorylation PhosphoSitePlus
T1794 Phosphorylation PhosphoSitePlus
S1799 Phosphorylation PhosphoSitePlus
Y1802 Phosphorylation PhosphoSitePlus
T1816 Phosphorylation PhosphoSitePlus
T1862 O-Glycosylation GlyGen 30459171, 25813380
S1869 O-Glycosylation GlyGen 30459171
T1876 O-Glycosylation GlyGen 30459171
T1896 O-Glycosylation GlyGen 25813380
T1926 O-Glycosylation GlyGen 30459171, 25813380
T2005 Phosphorylation PhosphoSitePlus
Y2023 Phosphorylation PhosphoSitePlus
S2057 Phosphorylation PhosphoSitePlus
S2061 Phosphorylation PhosphoSitePlus
T2063 Phosphorylation PhosphoSitePlus
S2112 Phosphorylation PhosphoSitePlus
N2121 N-Glycosylation GlyGen   UniProt 12754519
T2138 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S2140 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
S2143 O-Glycosylation GlyGen 25813380
T2145 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S2150 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T2151 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T2151 Phosphorylation PhosphoSitePlus
S2160 O-Glycosylation GlyGen 25813380
S2161 O-Glycosylation GlyGen 25813380
S2191 Phosphorylation PhosphoSitePlus
T2223 O-Glycosylation GlyGen 25813380
S2284 Phosphorylation PhosphoSitePlus
S2398 Phosphorylation PhosphoSitePlus
S2402 Phosphorylation PhosphoSitePlus
S2429 O-Glycosylation GlyGen 30459171
S2476 Phosphorylation PhosphoSitePlus
S2486 Phosphorylation PhosphoSitePlus
S2529 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S2541 O-Glycosylation GlyGen 25813380
S2559 O-Glycosylation GlyGen 30459171, 25813380
T2591 O-Glycosylation GlyGen 25813380
S2627 O-Glycosylation GlyGen 25813380
S2637 O-Glycosylation GlyGen 30459171
S2638 O-Glycosylation GlyGen 30459171
T2646 O-Glycosylation GlyGen 30459171
S2691 Phosphorylation PhosphoSitePlus
S2716 O-Glycosylation GlyGen 30459171
S2719 O-Glycosylation GlyGen 30459171
S2721 O-Glycosylation GlyGen 30459171
S2815 O-Glycosylation GlyGen 30459171
S2816 O-Glycosylation GlyGen 30459171
T2843 Phosphorylation HPRD   PhosphoSitePlus 20068231
S2964 Phosphorylation PhosphoSitePlus
S2986 Phosphorylation PhosphoSitePlus
T3032 O-Glycosylation GlyGen 30459171
S3040 Phosphorylation PhosphoSitePlus
N3072 N-Glycosylation GlyGen   UniProt 23090970, 19159218, 24190977
S3151 Phosphorylation PhosphoSitePlus
T3152 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T3262 Phosphorylation PhosphoSitePlus
T3392 O-Glycosylation GlyGen 30459171
S3393 O-Glycosylation GlyGen 30459171
S3398 O-Glycosylation GlyGen 30459171
T3399 O-Glycosylation GlyGen 30459171
T3401 O-Glycosylation GlyGen 30459171
T3405 O-Glycosylation GlyGen 30459171
S3412 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S3488 Phosphorylation PhosphoSitePlus
T3521 O-Glycosylation GlyGen 25813380
S3630 O-Glycosylation GlyGen 30459171
S3630 Phosphorylation PhosphoSitePlus
S3712 Phosphorylation PhosphoSitePlus
T3714 Phosphorylation PhosphoSitePlus
T3767 Phosphorylation PhosphoSitePlus
N3780 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
T3782 Phosphorylation PhosphoSitePlus
S3783 Phosphorylation PhosphoSitePlus
N3836 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
N4068 N-Glycosylation GlyGen   UniProt 29741879, 19159218
S4171 O-Glycosylation GlyGen 34019948, 28657654
S4193 O-Glycosylation GlyGen   UniProt 25326458, 36213313, 32337544
S4306 Phosphorylation PhosphoSitePlus
T4386 O-Glycosylation GlyGen 25813380
Site PTM Type PTM Enzyme Score Source PMID
N3780 N-Glycosylation PRO 29741879


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T49 A49 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T251 M251 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S279 F279 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T478 I478 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T563 M563 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T887 I887 Biomuta DOID:4159 / skin cancer [ cosmic ]
S888 F888 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T972 M972 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T1147 M1147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1896 I1896 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T2005 I2005 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T2138 S2138 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2140 F2140 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2150 I2150 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2160 F2160 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2161 L2161 Biomuta [ cosmic ]
S2486 L2486 Biomuta DOID:363 / uterine cancer [ icgc ]
S2559 R2559 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S2691 L2691 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2716 G2716 Biomuta DOID:1324 / lung cancer [ cosmic ]
N3072 Y3072 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T3152 P3152 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T3152 A3152 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T3405 M3405 Biomuta DOID:1324 / lung cancer [ cosmic ]
S3488 L3488 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
T3782 I3782 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S3783 F3783 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
N4068 S4068 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S4171 Y4171 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]