Protein Information

Cytoscape View

UniProt AC / UniProt ID P82970 / HMGN5_HUMAN
Protein Name High mobility group nucleosome-binding domain-containing protein 5
Gene Name Name: HMGN5
Organism Homo sapiens (Human)

PRO ID PR:P82970
DAG View
PRO Name high mobility group nucleosome-binding domain-containing protein 5 (human)
Definition A nucleosome-binding protein 1 that is encoded in the genome of human.
Short Label hHMGN5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P82970 (HMGN5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K5 Acetylation PhosphoSitePlus
K5 Methylation PhosphoSitePlus
S20 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22267324, 18669648, 18212344
S20 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
S24 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22267324, 18669648, 18212344
S24 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
T31 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18847512, 18234856, ...18669648, 20068231
T31 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
T31 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K67 Sumoylation PhosphoSitePlus
Y76 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
S93 Phosphorylation PhosphoSitePlus   UniProt 23186163
K95 Acetylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K101 Sumoylation PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
K124 Sumoylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 Y20 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S42 * Biomuta DOID:4362 / cervical cancer [ tcga ]
S42 L42 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K111 R111 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K149 Q149 Biomuta DOID:10534 / stomach cancer [ cosmic ]