iPTMnet Report for P81274 (GPSM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P81274 / GPSM2_HUMAN
Protein Name G-protein-signaling modulator 2
Gene Name Name: GPSM2
Synonyms:LGN;
Organism Homo sapiens (Human)

PRO ID PR:P81274
DAG View
PRO Name G-protein-signaling modulator 2 (human)
Definition A G-protein-signaling modulator 2 that is encoded in the genome of human.
Short Label hGPSM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P81274 (GPSM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K103 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
K266 Acetylation IEDB 34357683
C285 Methylation IEDB 31844290
C325 Methylation IEDB 31844290
S408 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 20068231, 20933426
S408 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 20933426
T418 Phosphorylation HPRD   PhosphoSitePlus 20068231
S427 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
T457 Phosphorylation PhosphoSitePlus   Signor 20589935
T457 Phosphorylation Q96KB5 (PBK) PhosphoSitePlus   Signor 20589935
S459 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
T461 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
S483 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
T486 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S497 Phosphorylation PhosphoSitePlus
T518 Phosphorylation HPRD 20068231
S520 Phosphorylation HPRD   PhosphoSitePlus 20068231
T521 Phosphorylation HPRD   PhosphoSitePlus 20068231
T522 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
T526 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S541 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
T544 Phosphorylation HPRD   PhosphoSitePlus 18669648
S554 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S565 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S567 Phosphorylation HPRD   PhosphoSitePlus 20068231
S607 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
T658 Phosphorylation PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S524 T524 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S524 F524 Biomuta DOID:4159 / skin cancer [ cosmic ]
T544 M544 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S567 T567 Biomuta DOID:3571 / liver cancer [ cosmic ]
T658 A658 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S677 A677 Biomuta DOID:363 / uterine cancer [ icgc ]
S681 L681 Biomuta DOID:363 / uterine cancer [ icgc ]