iPTMnet Report for P80303 (NUCB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P80303 / NUCB2_HUMAN
Protein Name Nucleobindin-2 precursor
Gene Name Name: NUCB2
Synonyms:NEFA;
Organism Homo sapiens (Human)

PRO ID PR:P80303
DAG View
PRO Name nucleobindin-2 (human)
Definition A nucleobindin-2 that is encoded in the genome of human.
Short Label hNUCB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P80303 (NUCB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T32 O-Glycosylation GlyGen 25813380
S42 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S42 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
T67 O-Glycosylation GlyGen 34019948, 33465208
T67 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
S96 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T101 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T163 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S164 Phosphorylation PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
T172 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K178 Acetylation PhosphoSitePlus
K201 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   UniProt 19690332
K272 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
T314 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T322 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S332 Phosphorylation PhosphoSitePlus   UniProt 20068231
T343 Phosphorylation PhosphoSitePlus
Y350 Phosphorylation IEDB 35494241
K386 Ubiquitination PhosphoSitePlus
Y389 O-Glycosylation GlyGen 23584533, 23399548, 25813380
Y389 Phosphorylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
S408 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
Site PTM Type PTM Enzyme Score Source PMID
S332 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y54 H54 Biomuta DOID:363 / uterine cancer [ cosmic ]
K90 T90 Biomuta DOID:263 / kidney cancer [ cosmic ]
S152 F152 Biomuta DOID:4159 / skin cancer [ cosmic ]
S152 C152 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T163 I163 Biomuta DOID:1324 / lung cancer [ cosmic ]
K171 N171 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S408 L408 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]