iPTMnet Report for P78549 (NTHL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P78549 / NTH_HUMAN
Protein Name Endonuclease III-like protein 1 precursor
Gene Name Name: NTHL1
Synonyms:NTH1,OCTS3;
Organism Homo sapiens (Human)

PRO ID PR:P78549
DAG View
PRO Name endonuclease III-like protein 1 (human)
Definition An endonuclease III-like protein 1 that is encoded in the genome of human.
Short Label hNTHL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78549 (NTHL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S71 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S73 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
K83 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
C306 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 L71 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K83 R83 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K106 T106 Biomuta DOID:1612 / breast cancer [ cosmic ]
K106 E106 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T160 K160 Biomuta DOID:3571 / liver cancer [ cosmic ]
S163 N163 Biomuta DOID:1319 / brain cancer [ cosmic ]
T171 M171 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y177 H177 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]