Protein Information

Cytoscape View


UniProt AC / UniProt ID P78536 / ADA17_HUMAN
Protein Name Disintegrin and metalloproteinase domain-containing protein 17 precursor
Gene Name Name: ADAM17
Synonyms:CSVP,TACE;
Organism Homo sapiens (Human)

PRO ID PR:P78536
DAG View
PRO Name disintegrin and metalloproteinase domain-containing protein 17 (human)
Definition An ADAM 17 endopeptidase that is encoded in the genome of human.
Short Label hADAM17
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78536 (ADAM17) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y82 Phosphorylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
N103 N-Glycosylation GlyGen 23090970, 24190977
N157 N-Glycosylation GlyGen 29741879
K168 Ubiquitination PhosphoSitePlus
N174 N-Glycosylation GlyGen 23090970, 24190977
K182 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
N264 N-Glycosylation GlyGen 23090970, 29741879, 24190977
K302 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
Y379 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S382 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K388 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
N452 N-Glycosylation GlyGen 29741879
K460 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
N539 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N551 N-Glycosylation GlyGen 29741879
N594 N-Glycosylation GlyGen 23090970, 24190977
N598 N-Glycosylation GlyGen 24190977
K620 Ubiquitination PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
T735 Phosphorylation P17252 (PRKCA) , P27361 (MAPK3) , P28482 (MAPK1) , Q05655 (PRKCD) , Q02156 (PRKCE) , Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32197276, 18722532, 30833304, ...20188673, 32319605, 12058067, 21570469, 30297396, 33260349, 18187448, 22384041, 15923650
S747 Phosphorylation PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
T761 Phosphorylation PhosphoSitePlus   UniProt 23186163
S767 Phosphorylation PhosphoSitePlus
T768 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
S791 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 12621058, 20068231
T796 Phosphorylation PhosphoSitePlus
K805 Ubiquitination PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
S819 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12621058
Site PTM Type PTM Enzyme Score Source PMID
Y379 Phosphorylation HPRD 17081983
S382 Phosphorylation HPRD 17081983
S791 Phosphorylation HPRD 19651622, 12621058, 18669648, ...20068231
S819 Phosphorylation HPRD 12621058


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T84 P84 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K388 N388 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
N452 K452 Biomuta DOID:3571 / liver cancer [ icgc ]
N539 D539 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K620 N620 Biomuta DOID:363 / uterine cancer [ tcga ]
S747 L747 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1909 / melanoma [ cosmic ]
S791 * Biomuta DOID:3571 / liver cancer [ icgc ]
T796 M796 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]