iPTMnet Report for P78362 (SRPK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P78362 / SRPK2_HUMAN
Protein Name SRSF protein kinase 2
Gene Name Name: SRPK2
Organism Homo sapiens (Human)

PRO ID PR:P78362
DAG View
PRO Name SRSF protein kinase 2 (human)
Definition An SRSF protein kinase 2 that is encoded in the genome of human.
Short Label hSRPK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78362 (SRPK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus   UniProt 24275569
K110 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
C320 S-Nitrosylation dbSNO 26338901
K326 Ubiquitination PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus   UniProt 18691976, 20068231, 24275569
S423 Phosphorylation PhosphoSitePlus
Y427 Phosphorylation PhosphoSitePlus
S483 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S484 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S490 O-Glycosylation GlyGen 30059200, 33657401
T492 O-Glycosylation GlyGen 30059200, 33657401
T492 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19592491
T492 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 19592491
S494 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S496 Phosphorylation PhosphoSitePlus
S497 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 18669648, ...24275569, 20068231
T498 O-Glycosylation GlyGen 30059200, 33657401
T498 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
K503 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
C535 Methylation IEDB 31844290
K539 Acetylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
R548 Methylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
S640 O-Glycosylation GlyGen 30059200, 33657401
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 19651622
Y319 Phosphorylation HPRD 15592455
S380 Phosphorylation HPRD 17322306, 18691976, 19651622, ...20068231, 18452278
S483 Phosphorylation HPRD 18669648
S484 Phosphorylation HPRD 18669648
T492 Phosphorylation HPRD 18691976
S494 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 15144186, 19651622, 18669648, 20068231
S496 Phosphorylation HPRD 17081983
S497 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19651622, 18669648, 20068231, 17081983
T498 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19415658, 15144186
T547 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y330 Phosphorylation HPRD 15592455
S391 Phosphorylation HPRD 17322306, 18691976, 19651622, ...20068231, 18452278
S494 Phosphorylation HPRD 18669648
S495 Phosphorylation HPRD 18669648
T503 Phosphorylation HPRD 18691976
S505 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 15144186, 19651622, 18669648, 20068231
S507 Phosphorylation HPRD 17081983
S508 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19651622, 18669648, 20068231, 17081983
T509 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19415658, 15144186
T558 Phosphorylation HPRD 18691976


P78362 (SRPK2) as PTM Enzyme



Substrate Site Score Source PMID
Q9UKV3 (ACIN1) S1180 neXtProt   PhosphoSitePlus   Signor 21056976, 18559500, 19592491


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S52 T52 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K179 R179 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K300 T300 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y319 C319 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y330 C330 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T376 M376 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S497 R497 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T498 A498 Biomuta DOID:1324 / lung cancer [ cosmic ]
S508 R508 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T509 A509 Biomuta DOID:1324 / lung cancer [ cosmic ]
K527 T527 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R548 H548 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K637 T637 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S640 G640 Biomuta DOID:9256 / colorectal cancer [ cosmic ]