iPTMnet Report for P78352 (DLG4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P78352 / DLG4_HUMAN
Protein Name Disks large homolog 4
Gene Name Name: DLG4
Synonyms:PSD95;
Organism Homo sapiens (Human)

PRO ID PR:P78352
DAG View
PRO Name disks large homolog 4 (human)
Definition A disks large homolog 4 that is encoded in the genome of human.
Short Label hDLG4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78352 (DLG4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus
T19 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus   RLIMS-P 17156196, 19081375
S78 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
T287 Phosphorylation P53778 (MAPK12) , P28482 (MAPK1) , O15264 (MAPK13) neXtProt   RLIMS-P 14741046
S290 Phosphorylation P53778 (MAPK12) neXtProt   RLIMS-P 14741046
S295 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus   RLIMS-P 17988632
Y397 Phosphorylation PhosphoSitePlus   RLIMS-P 21965656
K403 Ubiquitination PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
Y523 Phosphorylation P06241 (FYN) , P12931 (SRC) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 24981431, 22709448, 18721130
S561 Phosphorylation Q7KZI7 (MARK2) neXtProt   PhosphoSitePlus   RLIMS-P 28790172, 22807451
Y573 Phosphorylation PhosphoSitePlus
Y701 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P78352 (DLG4) Y523 Q14289 (PTK2B) decreased_association eFIP 24981431
Phosphorylation Q15768 (EFNB3) S332 P78352 (DLG4) inhibited_association eFIP 26479588


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P63142-1 (rKCNA2/iso:1) Interaction PR:P78352 (hDLG4) PRO 17959782


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T19 M19 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S25 R25 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S116 I116 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S142 F142 Biomuta DOID:4159 / skin cancer [ cosmic ]
S290 F290 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y573 N573 Biomuta DOID:263 / kidney cancer [ cosmic ]