iPTMnet Report for P78347 (GTF2I)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P78347 / GTF2I_HUMAN
Protein Name General transcription factor II-I
Gene Name Name: GTF2I
Synonyms:BAP135,WBSCR6;
Organism Homo sapiens (Human)

PRO ID PR:P78347
DAG View
PRO Name general transcription factor II-I (human)
Definition A general transcription factor II-I that is encoded in the genome of human.
Short Label hGTF2I
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78347 (GTF2I) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
T8 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus   UniProt 23186163
T24 O-Glycosylation GlyGen 33465208
S32 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...30379171, 34725712, 34019948, 25367160, 35132862, 35083852, 32119511, 28510447, 33465208
K74 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K86 Sumoylation PhosphoSitePlus
K94 Sumoylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
R101 Methylation PhosphoSitePlus
S103 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 20068231
T111 Phosphorylation PhosphoSitePlus
C121 Methylation IEDB 31844290
C121 S-Nitrosylation dbSNO 26338901
C123 S-Nitrosylation dbSNO 26338901
K130 Sumoylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K140 Sumoylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
R143 Methylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K177 Sumoylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
R206 Methylation PhosphoSitePlus
S207 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S210 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
S214 Phosphorylation PhosphoSitePlus   UniProt 23186163
C215 Methylation IEDB 31844290
K219 Methylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K221 Sumoylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
K240 Sumoylation PhosphoSitePlus
Y248 Phosphorylation P12931 (SRC) , Q06187 (BTK) , O60674 (JAK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15664986, 11934902, 11373296, ...20568114, 11313464, 16738337
Y249 Phosphorylation P12931 (SRC) PhosphoSitePlus 20568114
H278 Phosphorylation UniProt 24275569
H298 Phosphorylation UniProt 24275569
Y318 Phosphorylation phospho.ELM 11934902, 9837922
S319 Phosphorylation PhosphoSitePlus
K326 Sumoylation PhosphoSitePlus
K343 Acetylation PhosphoSitePlus
K343 Methylation PhosphoSitePlus
K343 Sumoylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
K353 Sumoylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K363 Sumoylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K372 Acetylation PhosphoSitePlus
K372 Sumoylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K378 Sumoylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
Y398 Phosphorylation Q06187 (BTK) phospho.ELM   PhosphoSitePlus   UniProt 11373296
S412 Phosphorylation Q13976 (PRKG1) neXtProt   PhosphoSitePlus   Signor   UniProt 23186163, 12082086
T413 Phosphorylation PhosphoSitePlus
K435 Sumoylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K450 Acetylation PhosphoSitePlus
K450 Sumoylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
K456 Methylation PhosphoSitePlus
K456 Sumoylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus
C475 S-Nitrosylation dbSNO 20140087, 22178444
K476 Ubiquitination PhosphoSitePlus
K477 Acetylation PhosphoSitePlus
K477 Sumoylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K488 Sumoylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K494 Sumoylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
Y503 Phosphorylation Q06187 (BTK) phospho.ELM   PhosphoSitePlus   UniProt 11373296
S515 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S517 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...18220336
Y519 Phosphorylation PhosphoSitePlus
K526 Sumoylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus
T556 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 18847512
T558 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18847512, 18669648, ...19690332, 20068231
K561 Acetylation PhosphoSitePlus
K561 Sumoylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
K640 Sumoylation PhosphoSitePlus
K645 Sumoylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
T663 Phosphorylation PhosphoSitePlus
K664 Sumoylation PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
S668 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) PhosphoSitePlus   Signor   UniProt 21406692, 10648599
S674 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) IEDB   PhosphoSitePlus   Signor   UniProt 23186163, 33936100, 32157095, ...10648599, 30784271, 31848261, 27869121
S677 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S679 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T687 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T698 Phosphorylation phospho.ELM 18669648
S699 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T703 Phosphorylation PhosphoSitePlus
T705 Phosphorylation PhosphoSitePlus
K715 Acetylation PhosphoSitePlus
K715 Methylation PhosphoSitePlus
K715 Sumoylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus   UniProt 23186163
K729 Ubiquitination PhosphoSitePlus
K734 Sumoylation PhosphoSitePlus
K736 Sumoylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K744 Sumoylation PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
K752 Sumoylation PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
Y770 Phosphorylation PhosphoSitePlus
S784 Phosphorylation Q13976 (PRKG1) neXtProt   PhosphoSitePlus   Signor   UniProt 23186163, 12082086
T785 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...30379171, 34725712, 34019948, 25367160, 35132862, 35083852, 32119511, 28510447, 33465208
T785 Phosphorylation PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
K807 Sumoylation PhosphoSitePlus
K807 Ubiquitination PhosphoSitePlus
K816 Sumoylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
S821 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus   UniProt 20068231, 24275569
K827 Ubiquitination PhosphoSitePlus
S830 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S831 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T836 Phosphorylation PhosphoSitePlus
T837 Phosphorylation PhosphoSitePlus
S839 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T850 Phosphorylation phospho.ELM 18669648
K861 Sumoylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
K879 Sumoylation PhosphoSitePlus
K879 Ubiquitination PhosphoSitePlus
K891 Sumoylation PhosphoSitePlus
K891 Ubiquitination PhosphoSitePlus
Y894 Phosphorylation PhosphoSitePlus
K896 Sumoylation PhosphoSitePlus
K896 Ubiquitination PhosphoSitePlus
Y920 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
R927 Methylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
K982 Sumoylation PhosphoSitePlus
S988 Phosphorylation PhosphoSitePlus
K991 Sumoylation PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S95 Phosphorylation HPRD 18452278
S103 Phosphorylation HPRD 18669648, 19664994, 20068231, ...18452278
T111 Phosphorylation HPRD 18452278
T202 Phosphorylation HPRD 20068231
S207 Phosphorylation HPRD 18669648, 20068231
S210 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19664994, 19664995, 18669648, 20068231
Y248 Phosphorylation O60674 (JAK2) , P12931 (SRC) , Q06187 (BTK) HPRD 9012831, 9837922, 11313464, ...11373296, 11934902
Y398 Phosphorylation Q06187 (BTK) HPRD 11373296
S412 Phosphorylation Q13976 (PRKG1) HPRD 12082086
Y503 Phosphorylation Q06187 (BTK) HPRD 11373296, 20068231
S515 Phosphorylation HPRD 18691976, 18669648, 20068231
S517 Phosphorylation HPRD 18669648, 15302935
T556 Phosphorylation HPRD 18669648, 19664995, 20068231, ...18452278
T558 Phosphorylation HPRD 18669648, 17924679, 19664995, ...20068231, 18452278
Y652 Phosphorylation P12931 (SRC) HPRD 11934902
S668 Phosphorylation HPRD 15302935, 20068231
S674 Phosphorylation HPRD 15302935, 20068231
S677 Phosphorylation HPRD 18669648, 20068231, 18452278
S679 Phosphorylation HPRD 19413330, 18669648, 17081983, ...18452278
T687 Phosphorylation HPRD 18669648, 17081983
T698 Phosphorylation HPRD 18669648
S699 Phosphorylation HPRD 18669648
S710 Phosphorylation HPRD 20068231
S784 Phosphorylation Q13976 (PRKG1) HPRD 19651622, 12082086, 20068231
S823 Phosphorylation HPRD 17081983, 20068231
S830 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S831 Phosphorylation HPRD 18669648, 18452278
T837 Phosphorylation HPRD 18452278
S839 Phosphorylation HPRD 18669648
T850 Phosphorylation HPRD 18669648
S877 Phosphorylation HPRD 20068231
Y920 Phosphorylation HPRD 20068231
S925 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S95 Phosphorylation HPRD 18452278
S103 Phosphorylation HPRD 18669648, 19664994, 20068231, ...18452278
T111 Phosphorylation HPRD 18452278
T202 Phosphorylation HPRD 20068231
S207 Phosphorylation HPRD 18669648, 20068231
S210 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19664994, 19664995, 18669648, 20068231
K240 Sumoylation PhosphoSitePlus
Y248 Phosphorylation Q06187 (BTK) , P12931 (SRC) , O60674 (JAK2) HPRD   neXtProt   PhosphoSitePlus 9837922, 11313464, 11934902, ...9012831, 11373296
Y249 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
S278 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y357 Phosphorylation Q06187 (BTK) HPRD   neXtProt   PhosphoSitePlus 11373296
S371 Phosphorylation Q13976 (PRKG1) HPRD   PhosphoSitePlus 16055503, 12082086
Y462 Phosphorylation Q06187 (BTK) HPRD   neXtProt   PhosphoSitePlus 20068231, 11373296
S474 Phosphorylation HPRD 18691976, 18669648, 20068231
S476 Phosphorylation HPRD 18669648, 15302935
T515 Phosphorylation HPRD 18669648, 19664995, 20068231, ...18452278
T517 Phosphorylation HPRD 18669648, 17924679, 19664995, ...20068231, 18452278
Y611 Phosphorylation P12931 (SRC) HPRD   PhosphoSitePlus 11934902
S627 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   neXtProt   PhosphoSitePlus 15302935, 10648599, 20068231
S633 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD   neXtProt   PhosphoSitePlus 15302935, 10648599, 20068231
S636 Phosphorylation HPRD 18669648, 20068231, 18452278
S638 Phosphorylation HPRD 19413330, 18669648, 17081983, ...18452278
T646 Phosphorylation HPRD 18669648, 17081983
T657 Phosphorylation HPRD 18669648
S658 Phosphorylation HPRD 18669648
S669 Phosphorylation HPRD 20068231
Y729 Phosphorylation PhosphoSitePlus
S743 Phosphorylation Q13976 (PRKG1) HPRD   PhosphoSitePlus 19651622, 12082086, 20068231, ...16055503
T744 Phosphorylation PhosphoSitePlus
S782 Phosphorylation HPRD 17081983, 20068231
S789 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S790 Phosphorylation HPRD 18669648, 18452278
T796 Phosphorylation HPRD 18452278
S798 Phosphorylation HPRD 18669648
T809 Phosphorylation HPRD 18669648
S836 Phosphorylation HPRD 20068231
Y879 Phosphorylation HPRD 20068231
S884 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S95 Phosphorylation HPRD 18452278
S103 Phosphorylation HPRD 18669648, 19664994, 20068231, ...18452278
T111 Phosphorylation HPRD 18452278
T202 Phosphorylation HPRD 20068231
S207 Phosphorylation HPRD 18669648, 20068231
S210 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19664994, 19664995, 18669648, 20068231
Y248 Phosphorylation Q06187 (BTK) , O60674 (JAK2) , P12931 (SRC) HPRD 9012831, 9837922, 11313464, ...11373296, 11934902
Y378 Phosphorylation Q06187 (BTK) HPRD 11373296
S392 Phosphorylation Q13976 (PRKG1) HPRD 12082086
Y483 Phosphorylation Q06187 (BTK) HPRD 11373296, 20068231
S495 Phosphorylation HPRD 18691976, 18669648, 20068231
S497 Phosphorylation HPRD 18669648, 15302935
T536 Phosphorylation HPRD 18669648, 19664995, 20068231, ...18452278
T538 Phosphorylation HPRD 18669648, 17924679, 19664995, ...20068231, 18452278
Y632 Phosphorylation P12931 (SRC) HPRD 11934902
S648 Phosphorylation HPRD 15302935, 10648599, 20068231
S654 Phosphorylation HPRD 15302935, 10648599, 20068231
S657 Phosphorylation HPRD 18669648, 20068231, 18452278
S659 Phosphorylation HPRD 19413330, 18669648, 17081983, ...18452278
T667 Phosphorylation HPRD 18669648, 17081983
T678 Phosphorylation HPRD 18669648
S679 Phosphorylation HPRD 18669648
S690 Phosphorylation HPRD 20068231
S764 Phosphorylation Q13976 (PRKG1) HPRD 19651622, 12082086, 20068231
S803 Phosphorylation HPRD 17081983, 20068231
S810 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S811 Phosphorylation HPRD 18669648, 18452278
T817 Phosphorylation HPRD 18452278
S819 Phosphorylation HPRD 18669648
T830 Phosphorylation HPRD 18669648
S857 Phosphorylation HPRD 20068231
Y900 Phosphorylation HPRD 20068231
S905 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S95 Phosphorylation HPRD 18452278
S103 Phosphorylation HPRD 18669648, 19664994, 20068231, ...18452278
T111 Phosphorylation HPRD 18452278
T202 Phosphorylation HPRD 20068231
S207 Phosphorylation HPRD 18669648, 20068231
S210 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19664994, 19664995, 18669648, 20068231
Y248 Phosphorylation O60674 (JAK2) , Q06187 (BTK) , P12931 (SRC) HPRD 9012831, 9837922, 11313464, ...11373296, 11934902
S298 Phosphorylation PhosphoSitePlus
Y377 Phosphorylation Q06187 (BTK) HPRD 11373296
S391 Phosphorylation Q13976 (PRKG1) HPRD 12082086
Y482 Phosphorylation Q06187 (BTK) HPRD 11373296, 20068231
S494 Phosphorylation HPRD 18691976, 18669648, 20068231
S496 Phosphorylation HPRD 18669648, 15302935
T535 Phosphorylation HPRD 18669648, 19664995, 20068231, ...18452278
T537 Phosphorylation HPRD 18669648, 17924679, 19664995, ...20068231, 18452278
Y631 Phosphorylation P12931 (SRC) HPRD 11934902
S647 Phosphorylation HPRD 15302935, 10648599, 20068231
S653 Phosphorylation HPRD 15302935, 10648599, 20068231
S656 Phosphorylation HPRD 18669648, 20068231, 18452278
S658 Phosphorylation HPRD 19413330, 18669648, 17081983, ...18452278
T666 Phosphorylation HPRD 18669648, 17081983
T677 Phosphorylation HPRD 18669648
S678 Phosphorylation HPRD 18669648
S689 Phosphorylation HPRD 20068231
S763 Phosphorylation Q13976 (PRKG1) HPRD 19651622, 12082086, 20068231
S802 Phosphorylation HPRD 17081983, 20068231
S809 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S810 Phosphorylation HPRD 18669648, 18452278
T816 Phosphorylation HPRD 18452278
S818 Phosphorylation HPRD 18669648
T829 Phosphorylation HPRD 18669648
S856 Phosphorylation HPRD 20068231
Y899 Phosphorylation HPRD 20068231
S904 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 Y16 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K94 T94 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R101 L101 Biomuta DOID:1324 / lung cancer [ cosmic ]
C121 F121 Biomuta DOID:3571 / liver cancer [ cosmic ]
C123 W123 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K130 I130 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K140 N140 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R143 Q143 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R143 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S146 L146 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S207 * Biomuta [ cosmic ]
S214 N214 Biomuta DOID:4159 / skin cancer [ cosmic ]
C215 S215 Biomuta DOID:3571 / liver cancer [ cosmic ]
K240 N240 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y251 C251 Biomuta DOID:1324 / lung cancer [ cosmic ]
S453 L453 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S627 P627 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S647 P647 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S648 P648 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S668 P668 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S798 * Biomuta [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S818 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S819 * Biomuta [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S839 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K879 E879 Biomuta DOID:1324 / lung cancer [ cosmic ]