iPTMnet Report for P78344 (EIF4G2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P78344 / IF4G2_HUMAN
Protein Name Eukaryotic translation initiation factor 4 gamma 2
Gene Name Name: EIF4G2
Synonyms:DAP5;ORFNames:OK/SW-cl.75;
Organism Homo sapiens (Human)

PRO ID PR:P78344
DAG View
PRO Name eukaryotic translation initiation factor 4 gamma 2 (human)
Definition A eukaryotic translation initiation factor 4 gamma 2 that is encoded in the genome of human.
Short Label hEIF4G2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78344 (EIF4G2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 12665801, ...22223895
S3 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus   UniProt 23186163
S14 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
R23 Methylation PhosphoSitePlus
K31 Methylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K41 Methylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus   UniProt 23186163
K92 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K233 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
C282 Methylation IEDB 31844290
S283 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
R360 Methylation PhosphoSitePlus   UniProt 24129315
K362 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
R393 Methylation PhosphoSitePlus
S395 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T397 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R400 Methylation PhosphoSitePlus
R402 Methylation PhosphoSitePlus
K431 Methylation PhosphoSitePlus   UniProt 24129315
K431 Ubiquitination PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus   UniProt 23186163
S448 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
R460 Methylation PhosphoSitePlus
K463 Methylation PhosphoSitePlus
K464 Methylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
R475 Methylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
R505 Methylation PhosphoSitePlus   UniProt 24129315
T506 O-Glycosylation GlyGen 23301498, 32938750, 35138101, ...34725712, 30059200, 28657654, 35254053, 34019948, 32870666, 32119511, 28510447, 33465208
T506 Phosphorylation PhosphoSitePlus
T508 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18088087, 15302935, 29530922, ...18669648, 24275569, 23186163, 19690332
T514 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K520 Ubiquitination PhosphoSitePlus
K529 Acetylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
R592 Methylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
Y642 Phosphorylation PhosphoSitePlus
R687 Methylation PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
S746 O-Glycosylation GlyGen 23301498, 35138101, 34725712, ...30059200, 28657654, 35254053, 34019948, 32870666, 32119511, 28510447, 33465208
Y751 Phosphorylation PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
C838 Methylation IEDB 31844290
K880 Ubiquitination PhosphoSitePlus
S902 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 21406692, 29530922, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S435 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 L17 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S17 W17 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K187 N187 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K187 Q187 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K204 N204 Biomuta DOID:363 / uterine cancer [ icgc ]
K206 R206 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S226 F226 Biomuta DOID:4159 / skin cancer [ cosmic ]
K233 R233 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K332 Q332 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R360 S360 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R360 M360 Biomuta DOID:363 / uterine cancer [ icgc ]
R393 K393 Biomuta DOID:4159 / skin cancer [ cosmic ]
R400 C400 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R402 C402 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S441 L441 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S454 L454 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R460 W460 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S479 L479 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R505 H505 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
R505 C505 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T514 S514 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K541 M541 Biomuta DOID:1324 / lung cancer [ cosmic ]
K541 N541 Biomuta DOID:363 / uterine cancer [ icgc ]
R592 I592 Biomuta DOID:1319 / brain cancer [ icgc ]
S605 C605 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R687 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K712 N712 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y751 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K761 R761 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S811 F811 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C838 S838 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]