Protein Information

Cytoscape View


UniProt AC / UniProt ID P78314 / 3BP2_HUMAN
Protein Name SH3 domain-binding protein 2
Gene Name Name: SH3BP2
Synonyms:3BP2;ORFNames:RES4-23;
Organism Homo sapiens (Human)

PRO ID PR:P78314
DAG View
PRO Name SH3 domain-binding protein 2 (human)
Definition An SH3 domain-binding protein 2 that is encoded in the genome of human.
Short Label hSH3BP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78314 (SH3BP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
Y174 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus 12709437, 15751964
Y183 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 19833725, 15751964, 11390470, ...12709437
S218 Phosphorylation PhosphoSitePlus
S225 Phosphorylation phospho.ELM   PhosphoSitePlus 12501243
S228 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
S278 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 15751964, ...24275569
T284 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus   UniProt 24275569
S425 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus   UniProt 23186163
K430 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
Y448 Phosphorylation P43405 (SYK) neXtProt   PhosphoSitePlus 12709437
Site PTM Type PTM Enzyme Score Source PMID
Y174 Phosphorylation P43405 (SYK) HPRD 12709437
Y183 Phosphorylation P43405 (SYK) HPRD 11390470
S278 Phosphorylation HPRD 18669648
Y448 Phosphorylation P43405 (SYK) HPRD 12709437
Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
R28 Methylation PhosphoSitePlus
R34 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T39 A39 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]