iPTMnet Report for P69905 (HBA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P69905 / HBA_HUMAN
Protein Name Hemoglobin subunit alpha
Gene Name Name: HBA2
Organism Homo sapiens (Human)

PRO ID PR:P69905
DAG View
PRO Name hemoglobin subunit alpha (human)
Definition A hemoglobin subunit alpha that is encoded in the genome of human.
Short Label hHBA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P69905 (HBA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 O-Glycosylation GlyGen   PhosphoSitePlus 18984734, 33214551, 34019948
S4 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
K8 Acetylation PhosphoSitePlus
T9 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
K12 Acetylation PhosphoSitePlus
K12 Methylation PhosphoSitePlus
K17 Acetylation PhosphoSitePlus   UniProt 19608861
K17 Ubiquitination PhosphoSitePlus
E24 Methylation IEDB 32357974
Y25 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18083107, 24275569
S36 O-Glycosylation GlyGen   PhosphoSitePlus 18984734, 33214551, 34019948
S36 Phosphorylation PhosphoSitePlus   UniProt 24275569
T39 Phosphorylation PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
Y43 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
S50 Phosphorylation PhosphoSitePlus   UniProt 24275569
S53 Phosphorylation HPRD   PhosphoSitePlus 20166139
K57 Acetylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
C105 S-Nitrosylation dbSNO 22178444, 17350155
T109 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S134 O-Glycosylation GlyGen   PhosphoSitePlus 18984734, 33214551, 34019948
T135 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
K140 Acetylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T39 P39 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T40 P40 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T42 P42 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S53 P53 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K61 T61 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T109 A109 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S134 R134 Biomuta DOID:4159 / skin cancer [ cosmic ]
T138 I138 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S139 C139 Biomuta DOID:4606 / bile duct cancer [ cosmic ]