Protein Information

Cytoscape View


UniProt AC / UniProt ID P68431 / H31_HUMAN
Protein Name Histone H3.1
Gene Name Name: H3C12
Synonyms:H3FA,HIST1H3A;Synonyms:H3FL,HIST1H3B;Synonyms:H3FC HIST1H3C;Synonyms:H3FB,HIST1H3D;Synonyms:H3FD,HIST1H3E;Synonyms:H3FI,HIST1H3F;Synonyms:H3FH,HIST1H3G;Synonyms:H3FK,HIST1H3H;Synonyms:H3FF,HIST1H3I;Synonyms:H3FJ,HIST1H3J;
Organism Homo sapiens (Human)

PRO ID PR:P68431
DAG View
PRO Name histone H3.1 (human)
Definition A histone H3 that is a translation product of any of the following genes in human: HIST1H3A/HIST1H3B/HIST1H3C/HIST1H3D/HIST1H3E/HIST1H3F/HIST1H3G/HIST1H3H/HIST1H3I/HIST1H3J.
Short Label hH3.1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P68431 (H3C12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
R3 Methylation UniProt 17898714, 18077460, 18079182
T4 Phosphorylation Q99986 (VRK1) phospho.ELM   PRO   UniProt 20705812, 20929775, 19622635, ...16185088, 20953165, 15681610, 17938195
K5 Acetylation PRO   UniProt 18552846, 17194708
K5 Methylation UniProt 16267050, 16457588, 17194708
T7 Phosphorylation PRO   UniProt 20228790
K10 Acetylation PRO   UniProt 20816089, 20972224, 16267050, ...19135889, 16627869, 16544193, 16457588, 17478518, 16497732, 17906200, 18337721, 17194708, 16185088, 17403718, 12419248, 21453398
K10 Methylation UniProt 16185088, 16267050, 16457588, ...17194708, 11242053
S11 O-Glycosylation GlyGen 21896475, 22371497, 28298630
S11 Phosphorylation P31751 (AKT2) , P51812 (RPS6KA3) , P11309 (PIM1) , P21980 (TGM2) , Q99986 (VRK1) , Q9UQB9 (AURKC) , Q96KB5 (PBK) , Q13153 (PAK1) , Q96GD4 (AURKB) , O14965 (AURKA) , Q16539 (MAPK14) , O75582 (RPS6KA5) neXtProt   phospho.ELM   PRO   Signor   UniProt 15249581, 10436156, 12588998, ...10464286, 12082625, 12560483, 15994958, 16457588, 16651411, 12151336, 16185088, 22158034, 15681610, 11856369, 15108802, 12677454, 16982762, 20626350, 16407273, 18256527, 14583461, 14625384, 17643117, 17938195
T12 Phosphorylation O14757 (CHEK1) , O43293 (DAPK3) neXtProt   phospho.ELM   PRO   UniProt 12560483, 18066052, 18243098
K15 Acetylation PRO   UniProt 16627869, 16267050, 16457588, ...16497732, 16678094, 17194708, 12419248, 16185088
R18 Methylation UniProt 15345777, 15471871, 16497732
K19 Acetylation PRO   UniProt 20978174, 16627869, 18552846, ...16267050, 15988529, 17194708, 20841388, 19349354, 18953329
K19 Methylation UniProt 16267050, 17194708
K24 Acetylation PRO   UniProt 21164480, 16267050, 16457588, ...17194708, 16627869
K24 Methylation UniProt 17194708
K28 Acetylation PRO   UniProt 18552846, 16627869, 20385584, ...17194708
K28 Methylation UniProt 16185088, 16267050, 17194708, ...16627869
S29 O-Glycosylation GlyGen 21896475, 22371497, 28298630
S29 Phosphorylation P45984 (MAPK9) , P27361 (MAPK3) , Q96GD4 (AURKB) , O75582 (RPS6KA5) , P28482 (MAPK1) , Q16539 (MAPK14) , P45983 (MAPK8) , P31751 (AKT2) HPRD   neXtProt   phospho.ELM   PRO   Signor   UniProt 11856369, 22158034, 10464286, ...12082625, 16457588, 19007248, 21282660, 11278789, 16185088, 15684425, 20129940, 15681610, 17924679
T33 O-Glycosylation GlyGen 21896475, 22371497, 28298630
K37 Acetylation PRO   PhosphoSitePlus   UniProt 17189264, 17194708, 18552846
K37 Methylation PhosphoSitePlus   UniProt 16627869, 16267050, 15983376, ...17194708, 16185088
K37 Ubiquitination PhosphoSitePlus
K38 Methylation UniProt 15983376
Y42 Phosphorylation PRO   UniProt 19783980
T46 O-Glycosylation GlyGen 21896475, 22371497, 28298630
T46 Phosphorylation P31751 (AKT2) , Q05655 (PRKCD) neXtProt   PRO   Signor 19363025, 22158034
K57 Acetylation PRO   UniProt 20587414, 19625767, 19270680, ...17194708
K57 Methylation UniProt 22387026, 17194708
S58 Phosphorylation UniProt 20850016
K65 Methylation UniProt 16267050, 17194708
K80 Acetylation UniProt 17194708
K80 Methylation UniProt 15525939, 16267050, 17194708, ...16627869
T81 Phosphorylation UniProt 20850016
S87 Phosphorylation PhosphoSitePlus
C97 S-Nitrosylation dbSNO 25040305
K116 Acetylation UniProt 19520870
K123 Acetylation UniProt 19520870, 23415232
K123 Methylation UniProt 16267050, 17194708


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 V1 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1612 / breast cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ tcga ]
M1 I1 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ] DOID:1324 / lung cancer [ tcga ]
R3 * Biomuta DOID:9256 / colorectal cancer [ tcga ]
R3 C3 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R3 H3 Biomuta DOID:10534 / stomach cancer [ tcga ] DOID:2994 / germ cell cancer [ tcga ] DOID:3070 / malignant glioma [ icgc, tcga ]
R3 G3 Biomuta DOID:1612 / breast cancer [ icgc, tcga ] DOID:10534 / stomach cancer [ cosmic ] DOID:2994 / germ cell cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:2394 / ovarian cancer [ tcga ]
R3 W3 Biomuta DOID:1909 / melanoma [ tcga ]
T4 S4 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T4 N4 Biomuta DOID:3571 / liver cancer [ icgc ]
T4 I4 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T4 A4 Biomuta DOID:1324 / lung cancer [ cosmic, cosmic, tcga ]
T4 M4 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T4 R4 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K5 M5 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K5 I5 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T7 I7 Biomuta DOID:3571 / liver cancer [ icgc ]
T7 K7 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ icgc ]
T7 A7 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K10 R10 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S11 F11 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S11 C11 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S11 T11 Biomuta DOID:363 / uterine cancer [ tcga ]
S11 Y11 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T12 A12 Biomuta DOID:1324 / lung cancer [ cosmic ]
T12 K12 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T12 M12 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T12 S12 Biomuta DOID:1324 / lung cancer [ cosmic ]
K15 * Biomuta DOID:363 / uterine cancer [ tcga ]
K15 R15 Biomuta DOID:1612 / breast cancer [ icgc ]
R18 C18 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:5041 / esophageal cancer [ tcga ]
R18 H18 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
R18 L18 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ tcga ]
R18 P18 Biomuta DOID:1324 / lung cancer [ cosmic ]
K19 Q19 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:263 / kidney cancer [ icgc, tcga ]
K19 M19 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K24 R24 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K28 M28 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:2531 / hematologic cancer [ tcga ]
K28 N28 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K28 E28 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K28 R28 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S29 R29 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S29 I29 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T33 A33 Biomuta DOID:1909 / melanoma [ cosmic ]
T33 S33 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K37 M37 Biomuta DOID:1909 / melanoma [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
K37 N37 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ tcga ]
K37 E37 Biomuta DOID:1324 / lung cancer [ cosmic ]
K37 R37 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
K37 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K38 N38 Biomuta DOID:3070 / malignant glioma [ icgc, tcga ]
K38 * Biomuta DOID:4362 / cervical cancer [ tcga ]
Y42 * Biomuta DOID:1324 / lung cancer [ tcga ]
T46 I46 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T46 N46 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K57 N57 Biomuta DOID:1324 / lung cancer [ tcga ]
K57 M57 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S58 W58 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S58 L58 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K65 N65 Biomuta DOID:1324 / lung cancer [ cosmic ]
K80 E80 Biomuta DOID:363 / uterine cancer [ tcga ]
K80 N80 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
T81 A81 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3963 / thyroid carcinoma [ tcga ]
T81 I81 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S87 R87 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S87 N87 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:2531 / hematologic cancer [ icgc ]
S87 C87 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S87 T87 Biomuta DOID:2531 / hematologic cancer [ tcga ]
C97 S97 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C97 F97 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
C97 Y97 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1909 / melanoma [ cosmic ] DOID:1324 / lung cancer [ tcga ]
K116 E116 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
K116 N116 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K123 T123 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K123 R123 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K123 N123 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ]