iPTMnet Report for P68133 (ACTA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P68133 / ACTS_HUMAN
Protein Name Actin, alpha skeletal muscle precursor
Gene Name Name: ACTA1
Synonyms:ACTA;
Organism Homo sapiens (Human)

PRO ID PR:P68133
DAG View
PRO Name actin, alpha skeletal muscle (human)
Definition An actin, alpha skeletal muscle that is encoded in the genome of human.
Short Label hACTA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P68133 (ACTA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R30 Methylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Methylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455, 18083107, 17389395
S62 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Sumoylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus
K70 Methylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Methylation PhosphoSitePlus   UniProt 23673617
K86 Sumoylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Methylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
R198 Methylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
S201 O-Glycosylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Methylation PhosphoSitePlus
Y220 Phosphorylation HPRD   PhosphoSitePlus 15592455
S235 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K240 Methylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
R256 Methylation PhosphoSitePlus
T262 O-Glycosylation GlyGen 23301498, 23271734, 30444036, ...30397120, 26374642, 33214551, 29351928, 34019948
T262 Phosphorylation PhosphoSitePlus
S267 O-Glycosylation GlyGen 23301498, 23271734, 30444036, ...30397120, 26374642, 33214551, 29351928, 34019948
S267 Phosphorylation PhosphoSitePlus
S273 O-Glycosylation GlyGen 23301498, 23271734, 30444036, ...30397120, 26374642, 33214551, 29351928, 34019948
T280 O-Glycosylation GlyGen 23301498, 23271734, 30444036, ...30397120, 26374642, 33214551, 29351928, 34019948
T280 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
K317 Sumoylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
K328 Acetylation PhosphoSitePlus
K328 Methylation PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
K330 Sumoylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K338 Sumoylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R30 S30 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R30 M30 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S35 Y35 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K63 N63 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T68 I68 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K193 R193 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K193 Q193 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T196 A196 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R198 C198 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S235 Y235 Biomuta DOID:1324 / lung cancer [ cosmic ]
S236 Y236 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S237 F237 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K240 E240 Biomuta DOID:2394 / ovarian cancer [ icgc ]
R256 C256 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S267 F267 Biomuta DOID:1319 / brain cancer [ icgc ]
S267 T267 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S283 N283 Biomuta DOID:4362 / cervical cancer [ icgc ]
Y296 F296 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y296 H296 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T306 M306 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K330 E330 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S370 Y370 Biomuta DOID:1324 / lung cancer [ cosmic ]