Protein Information

Cytoscape View

UniProt AC / UniProt ID P68104 / EF1A1_HUMAN
Protein Name Elongation factor 1-alpha 1
Gene Name Name: EEF1A1
Organism Homo sapiens (Human)

PRO ID PR:P68104
DAG View
PRO Name elongation factor 1-alpha 1 (human)
Definition An elongation factor 1-alpha 1 that is encoded in the genome of human.
Short Label hEEF1A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P68104 (EEF1A1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
G2 Methylation UniProt 26545399, 30143613
T6 Phosphorylation HPRD 20068231
K20 Acetylation PhosphoSitePlus
S21 Phosphorylation P15056 (BRAF) HPRD   PhosphoSitePlus   RLIMS-P 22378069, 25436588, 20068231
T22 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
T24 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y29 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 20068231, 16497976
K30 Acetylation PhosphoSitePlus
K30 Methylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
K36 Methylation PhosphoSitePlus   UniProt 28520920
K36 Ubiquitination PhosphoSitePlus
R37 Methylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K41 Sumoylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K44 Acetylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K51 Methylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Methylation PhosphoSitePlus   UniProt 30612740, 30143613
K55 Sumoylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
K62 Methylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
K79 Methylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Methylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
T88 Phosphorylation P15056 (BRAF) PhosphoSitePlus   RLIMS-P 22378069, 25436588
R96 Methylation PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
C111 S-Nitrosylation dbSNO 22178444
S128 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
R134 Methylation PhosphoSitePlus
Y141 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 17016520, 16497976
T142 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K154 Methylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
Y162 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 20068231
S163 Phosphorylation PhosphoSitePlus
K165 Methylation PhosphoSitePlus   UniProt 28108655
K165 Ubiquitination PhosphoSitePlus
R166 Methylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
K172 Acetylation PhosphoSitePlus
K172 Methylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K179 Methylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K180 Sumoylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Sumoylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K219 Sumoylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
C234 S-Nitrosylation dbSNO 16648260, 22178444
T239 Phosphorylation PhosphoSitePlus
T242 Phosphorylation HPRD   PhosphoSitePlus 20068231
K244 Acetylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
Y254 Phosphorylation HPRD   PhosphoSitePlus 18691976
K255 Acetylation PhosphoSitePlus
K255 Methylation PhosphoSitePlus
K255 Sumoylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
R266 Methylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
K273 Acetylation PhosphoSitePlus
K273 Sumoylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
N284 N-Glycosylation GlyGen 24190977
T286 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S300 Phosphorylation P36897 (TGFBR1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21776411, 20832312
K313 Sumoylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
K318 Acetylation PhosphoSitePlus
K318 Methylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
K385 Methylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K386 Acetylation PhosphoSitePlus
K386 Methylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K392 Acetylation PhosphoSitePlus
K392 Sumoylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K395 Acetylation PhosphoSitePlus
K395 Sumoylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
K408 Acetylation PhosphoSitePlus
K408 Methylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
C411 S-Nitrosylation dbSNO 19483679, 19101475, 22178444, ...26338901
S414 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
R430 Methylation PhosphoSitePlus
T432 Phosphorylation Q96RG2 (PASK) , O75116 (ROCK2) , Q05655 (PRKCD) HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 17595531, 7890750, 24405853, ...21418524, 20068231
K439 Acetylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K450 Acetylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
T452 Phosphorylation PhosphoSitePlus
K453 Acetylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
K460 Acetylation PhosphoSitePlus

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P68104 (EEF1A1) T432 Q96RG2 (PASK) unknown eFIP 21418524

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K20 N20 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T24 A24 Biomuta DOID:3571 / liver cancer [ tcga ]
Y29 C29 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ tcga ]
R37 K37 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
K41 * Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K44 E44 Biomuta DOID:169 / neuroendocrine tumor [ tcga ] DOID:3571 / liver cancer [ tcga ] DOID:1324 / lung cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
Y85 H85 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T106 A106 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R134 P134 Biomuta DOID:1612 / breast cancer [ tcga ]
R134 Q134 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
R134 G134 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T142 A142 Biomuta DOID:3571 / liver cancer [ icgc, tcga ]
K179 T179 Biomuta DOID:363 / uterine cancer [ tcga ]
K215 R215 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S224 G224 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
R266 Q266 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T269 S269 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S354 N354 Biomuta DOID:1909 / melanoma [ cosmic ]
R430 T430 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T432 S432 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
T432 I432 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:3070 / malignant glioma [ cosmic, tcga ] DOID:11934 / head and neck cancer [ tcga ]
T432 A432 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T452 N452 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1612 / breast cancer [ cosmic, icgc ]