iPTMnet Report for P68032 (ACTC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P68032 / ACTC_HUMAN
Protein Name Actin, alpha cardiac muscle 1 precursor
Gene Name Name: ACTC1
Synonyms:ACTC;
Organism Homo sapiens (Human)

PRO ID PR:P68032
DAG View
PRO Name actin, alpha cardiac muscle 1 (human)
Definition An actin, alpha cardiac muscle 1 that is encoded in the genome of human.
Short Label hACTC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P68032 (ACTC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R30 Methylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Methylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Sumoylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus
K70 Methylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Methylation PhosphoSitePlus   UniProt 23673617
K86 Sumoylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Methylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
R198 Methylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Methylation PhosphoSitePlus
C219 S-Nitrosylation dbSNO 25040305
Y220 Phosphorylation PhosphoSitePlus
T231 O-Glycosylation GlyGen 34105348
S235 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K240 Methylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
S302 O-Glycosylation GlyGen 23271734, 36240223, 26853435, ...34105348, 30397120
T306 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
K317 Sumoylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
K328 Acetylation PhosphoSitePlus
K328 Methylation PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
K330 Sumoylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K338 Sumoylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R30 H30 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R30 C30 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S35 F35 Biomuta DOID:4159 / skin cancer [ cosmic ]
S35 P35 Biomuta DOID:363 / uterine cancer [ icgc ]
K52 Q52 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S62 R62 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S62 N62 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K63 N63 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y71 C71 Biomuta DOID:3571 / liver cancer [ cosmic ]
T79 N79 Biomuta DOID:4159 / skin cancer [ cosmic ]
T91 S91 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y93 C93 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K115 E115 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T128 S128 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y168 H168 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y168 N168 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y171 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T188 N188 Biomuta DOID:1324 / lung cancer [ cosmic ]
T196 N196 Biomuta DOID:1324 / lung cancer [ cosmic ]
R198 S198 Biomuta DOID:3571 / liver cancer [ cosmic ]
R198 P198 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R198 C198 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R198 H198 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
Y200 F200 Biomuta DOID:1324 / lung cancer [ cosmic ]
S201 Y201 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K215 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y220 H220 Biomuta DOID:1324 / lung cancer [ cosmic ]
S236 F236 Biomuta DOID:4159 / skin cancer [ cosmic ]
K240 I240 Biomuta DOID:4159 / skin cancer [ cosmic ]
S241 G241 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T251 S251 Biomuta DOID:1324 / lung cancer [ cosmic ]
T280 P280 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S283 N283 Biomuta DOID:1612 / breast cancer [ icgc ]
T326 S326 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S370 C370 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]