iPTMnet Report for P67809 (YBX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P67809 / YBOX1_HUMAN
Protein Name Y-box-binding protein 1
Gene Name Name: YBX1
Synonyms:NSEP1;
Organism Homo sapiens (Human)

PRO ID PR:P67809
DAG View
PRO Name Y-box-binding protein 1 (human)
Definition A Y-box-binding protein 1 that is encoded in the genome of human.
Short Label hYBX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P67809 (YBX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation HPRD   PhosphoSitePlus 18491316
S3 Phosphorylation PhosphoSitePlus
T7 Phosphorylation HPRD   PhosphoSitePlus 20068231
S21 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
S32 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...21740066, 33465208, 34019948, 27751836, 32119511, 20305658, 31373491
S32 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T57 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...21740066, 33465208, 34019948, 27751836, 32119511, 20305658, 31373491
K58 Ubiquitination PhosphoSitePlus
T62 Phosphorylation RLIMS-P 32178290
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
T80 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
R101 Methylation PhosphoSitePlus
S102 Phosphorylation P51812 (RPS6KA3) , Q15418 (RPS6KA1) , P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28415756, 30356079, 32931865, ...26318844, 17875215, 24770864, 28123588, 32013098, 34272387, 16354698, 20844753, 15806160, 35022570, 33379356, 32112110, 31010234, 32710623, 24349210, 28107702, 21392397, 21423216, 27080258, 19664994, 33911076, 32028981, 19690332, 24554780, 19036157, 19651622, 30126195, 33516877, 17081983, 31906126, 26355086, 32973139, 27397581, 32178290, 24885403
T108 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
T126 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...21740066, 33465208, 34019948, 27751836, 32119511, 20305658, 31373491
S136 Phosphorylation PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus   UniProt 18851979
R142 Methylation PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
Y158 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y162 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18669648, 20068231
S165 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 18491316, ...23186163, 17081983, 26318844, 28077578, 32013098, 19664995, 18452278, 19651622, 19664994, 18669648, 19415658, 17322306, 18767875, 20166139, 19690332, 20068231
S167 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...19664994, 19664995, 18452278, 19651622, 17322306, 18669648, 19690332, 24275569, 20166139, 19415658, 20068231
K170 Ubiquitination PhosphoSitePlus
S174 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...18491316, 23186163, 17081983, 19664994, 19664995, 18452278, 19651622, 18669648, 19690332, 24275569, 20166139, 19415658, 20068231
S176 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 17322306, 21406692, ...23186163, 17081983, 32013098, 28077578, 19664994, 19664995, 18452278, 19651622, 18669648, 24275569, 19690332, 20068231
R185 Methylation PhosphoSitePlus
R186 Methylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
R189 Methylation PhosphoSitePlus
R190 Methylation PhosphoSitePlus
R192 Methylation PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
M198 Methylation IEDB 26929215, 25418920
R199 Methylation PhosphoSitePlus
R200 Methylation PhosphoSitePlus
R204 Methylation PhosphoSitePlus
R205 Methylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
S209 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...21740066, 33465208, 34019948, 27751836, 32119511, 20305658, 31373491
S209 Phosphorylation PhosphoSitePlus
R231 Methylation PhosphoSitePlus
R234 Methylation PhosphoSitePlus
Y238 Phosphorylation PhosphoSitePlus
R239 Methylation PhosphoSitePlus
R242 Methylation PhosphoSitePlus
R244 Methylation PhosphoSitePlus
K264 Methylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
T271 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...21740066, 33465208, 34019948, 27751836, 32119511, 20305658, 31373491
T271 Phosphorylation PhosphoSitePlus
R279 Methylation PhosphoSitePlus
R280 Methylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus   RLIMS-P 24103640
Y287 Phosphorylation PhosphoSitePlus
K296 Acetylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K301 Acetylation UniProt 19483673
K301 Ubiquitination PhosphoSitePlus
T303 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...21740066, 33465208, 34019948, 27751836, 32119511, 20305658, 31373491
K304 Acetylation UniProt 19483673
K304 Ubiquitination PhosphoSitePlus
S313 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...21740066, 33465208, 34019948, 27751836, 32119511, 20305658, 31373491
S313 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 19413330, 21695211, 20068231
S314 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 18491316, ...17287340, 17081983, 21695211, 19664995, 18452278, 19651622, 18669648, 18707149, 23186163, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P67809 (YBX1) S102 Q9NPI1 (BRD7) unknown eFIP 32028981


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T57 A57 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K64 I64 Biomuta DOID:1324 / lung cancer [ cosmic ]
K81 E81 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R101 C101 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T108 I108 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K137 T137 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R142 C142 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S174 L174 Biomuta DOID:4159 / skin cancer [ cosmic ]
R185 C185 Biomuta DOID:363 / uterine cancer [ icgc ]
R199 W199 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
R204 C204 Biomuta DOID:363 / uterine cancer [ icgc ]
R204 H204 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R205 * Biomuta DOID:3571 / liver cancer [ cosmic ]
R205 Q205 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R239 L239 Biomuta DOID:3571 / liver cancer [ cosmic ]
R239 W239 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R239 Q239 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R242 T242 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R242 K242 Biomuta DOID:4159 / skin cancer [ cosmic ]
R244 Q244 Biomuta [ cosmic ]
T271 I271 Biomuta DOID:363 / uterine cancer [ cosmic ]
R279 H279 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R279 C279 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y281 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y287 C287 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S313 L313 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S313 W313 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]