Protein Information

Cytoscape View


UniProt AC / UniProt ID P63244 / RACK1_HUMAN
Protein Name Receptor of activated protein C kinase 1
Gene Name Name: RACK1
Synonyms:GNB2L1;ORFNames:HLC7,PIG21;
Organism Homo sapiens (Human)

PRO ID PR:P63244
DAG View
PRO Name receptor of activated protein C kinase 1 (human)
Definition A receptor of activated protein C kinase 1 that is encoded in the genome of human.
Short Label hRACK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63244 (RACK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO   UniProt 22814378
T2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378
T2 Phosphorylation HPRD   PhosphoSitePlus 20058876
T6 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
R8 Methylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus   UniProt 23186163
K12 Methylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus
T50 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P 26549445
Y52 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor   UniProt 19423701
S63 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus   UniProt 23186163
K106 Ubiquitination PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
K130 Acetylation PhosphoSitePlus   UniProt 19608861
K130 Sumoylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
C138 S-Nitrosylation dbSNO 19483679, 26338901
K139 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
C168 S-Nitrosylation dbSNO 19483679
K172 Acetylation PhosphoSitePlus
K172 Methylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
C182 S-Nitrosylation dbSNO 19483679
K183 Acetylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
Y194 Phosphorylation P29597 (TYK2) phospho.ELM   PhosphoSitePlus   RLIMS-P 15240704
C207 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K212 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
Y228 Phosphorylation P12931 (SRC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15592455, 12400005, 11279199
C240 S-Nitrosylation dbSNO 26338901
R245 Methylation PhosphoSitePlus
Y246 Phosphorylation P12931 (SRC) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12400005, 22523568, 31143369
C249 S-Nitrosylation dbSNO 19483679, 22178444, 19366988, ...18335467
S255 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K271 Methylation PhosphoSitePlus
K271 Sumoylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus   UniProt 23186163, 28636603
T277 Phosphorylation UniProt 28636603
S278 Phosphorylation UniProt 28636603
S279 Phosphorylation UniProt 28636603
K280 Methylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus   RLIMS-P 18567578
T313 Phosphorylation HPRD   PhosphoSitePlus 20068231
T316 Phosphorylation HPRD   PhosphoSitePlus 18767875, 20068231
R317 Methylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036248 (hRACK1/Ac:1) acM1 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P63244 (RACK1) T50 Q6ZNE5 (ATG14) unknown eFIP 26549445
Phosphorylation P63244 (RACK1) T50 Q99570 (PIK3R4) unknown eFIP 26549445
Phosphorylation P63244 (RACK1) T50 Q14457 (BECN1) unknown eFIP 26549445


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K38 N38 Biomuta DOID:1324 / lung cancer [ tcga ]
T94 M94 Biomuta DOID:1909 / melanoma [ cosmic ]
T94 A94 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S146 R146 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S157 L157 Biomuta DOID:3571 / liver cancer [ icgc ]
S161 R161 Biomuta DOID:3571 / liver cancer [ icgc ]
Y194 * Biomuta DOID:363 / uterine cancer [ tcga ]
R245 H245 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
R245 C245 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K271 E271 Biomuta DOID:363 / uterine cancer [ tcga ]
S276 G276 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T277 N277 Biomuta DOID:3571 / liver cancer [ icgc ]
K280 E280 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]