Protein Information

Cytoscape View


UniProt AC / UniProt ID P63208 / SKP1_HUMAN
Protein Name S-phase kinase-associated protein 1
Gene Name Name: SKP1
Synonyms:EMC19,OCP2,SKP1A,TCEB1L;
Organism Homo sapiens (Human)

PRO ID PR:P63208
DAG View
PRO Name S-phase kinase-associated protein 1 (human)
Definition An S-phase kinase-associated protein 1A that is encoded in the genome of human.
Short Label hSKP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63208 (SKP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K22 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
K137 Ubiquitination PhosphoSitePlus
K142 Sumoylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
R154 Methylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
C160 S-Nitrosylation dbSNO 26338901
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 3212432
T131 Phosphorylation HPRD 17322306, 19651622, 18212344, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
T131 Phosphorylation HPRD 17322306, 19651622, 18212344, ...20068231


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P63208-1 (hSKP1/iso:1) Interaction PR:Q13616-1 (hCUL1/iso:1) PRO 12609982


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K80 R80 Biomuta DOID:1324 / lung cancer [ tcga ]
K128 Q128 Biomuta DOID:363 / uterine cancer [ tcga ]
K137 N137 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R154 S154 Biomuta DOID:3571 / liver cancer [ icgc ]