iPTMnet Report for P63104 (YWHAZ)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P63104 / 1433Z_HUMAN
Protein Name 14-3-3 protein zeta/delta
Gene Name Name: YWHAZ
Organism Homo sapiens (Human)

PRO ID PR:P63104
DAG View
PRO Name 14-3-3 protein zeta/delta (human)
Definition A 14-3-3 protein zeta/delta that is encoded in the genome of human.
Short Label hYWHAZ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63104 (YWHAZ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895, 25944712
K3 Acetylation PhosphoSitePlus   UniProt 19608861
K3 Methylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
C25 Methylation IEDB 31844290
C25 S-Nitrosylation dbSNO 25040305, 2212679, 22126794
K27 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
E31 Phosphorylation IntAct 11336675
S37 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
K49 Methylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S58 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9705322, 18559254, 12861023, ...35134439, 11956222, 12865427, 15037601, 16376338, 15883165
S58 Phosphorylation O00506 (STK25) neXtProt 15037601
S58 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 16376338
S58 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 11956222
S58 Phosphorylation P49137 (MAPKAPK2) neXtProt   PhosphoSitePlus   Signor 12861023
S58 Phosphorylation Q05655 (PRKCD) neXtProt   Signor 12861023, 9705322
S63 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus   UniProt 19608861
K68 Ubiquitination PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Methylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
C94 Methylation IEDB 31844290
C94 S-Nitrosylation dbSNO 19483679, 25040305
S99 Phosphorylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
Y126 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
K138 Acetylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
S184 O-Glycosylation GlyGen 23301498, 30444036, 18369606, ...35138101, 30397120, 26374642, 34725712, 33214551, 29351928, 34019948
S184 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15696159, 15071501, 16009721
S184 Phosphorylation P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15071501, 16009721
S184 Phosphorylation P45984 (MAPK9) Signor 15071501
S184 Phosphorylation P53779 (MAPK10) Signor 15071501
C189 S-Nitrosylation dbSNO 19483679
K193 Ubiquitination PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   UniProt 19690332, 20068231
S210 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Methylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
T232 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31024343, 17081983, 9360956, ...14613942, 16045749, 20068231
T232 Phosphorylation P11274 (BCR) PhosphoSitePlus 16045749
T232 Phosphorylation P48729 (CSNK1A1) neXtProt   PhosphoSitePlus   Signor 9360956
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S58 Phosphorylation HPRD 12861023, 16376338, 11956222, ...9705322, 15037601
S58 Phosphorylation O00506 (STK25) HPRD 15037601
S58 Phosphorylation P31749 (AKT1) HPRD 11956222
S58 Phosphorylation P49137 (MAPKAPK2) HPRD 12861023
S58 Phosphorylation Q05655 (PRKCD) HPRD 9705322
S184 Phosphorylation HPRD   PRO 15696159, 11956222
S184 Phosphorylation P31749 (AKT1) HPRD 11956222
S184 Phosphorylation P45983 (MAPK8) HPRD 15696159
T205 Phosphorylation HPRD 18452278
S207 Phosphorylation HPRD 19651622, 20166139, 19664994, ...20068231, 18452278
S210 Phosphorylation HPRD 19413330
S230 Phosphorylation HPRD 20068231
T232 Phosphorylation HPRD 18691976, 18077418, 18452278, ...19651622, 9360956, 19415658, 20068231
T232 Phosphorylation P48729 (CSNK1A1) HPRD 18691976, 18077418, 18452278, ...19651622, 9360956, 19415658, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036164 (hYWHAZ/Ac:1) acM1 PRO
PR:000044508 (hYWHAZ/Phos:1) pS184 PRO 15696159


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P18031 (PTPN1) S50 P63104 (YWHAZ) unknown eFIP 31873221
Phosphorylation P53350 (PLK1) S597 P63104 (YWHAZ) increased_association eFIP 22202082
Phosphorylation Q7Z3C6 (ATG9A) S761 P63104 (YWHAZ) increased_association eFIP 25266655


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000044506 (hABL1/Phos:1) Interaction PR:P63104 (hYWHAZ) PRO 15696159
PR:000044508 (hYWHAZ/Phos:1) decreased Interaction PR:000044506 (hABL1/Phos:1) PRO 15696159
PR:000044509 (hYWHAZ/UnPhos:1) Interaction PR:000044506 (hABL1/Phos:1) PRO 15696159
PR:000044510 (hCTNNB1/iso:1/Phos:14) Interaction PR:P63104 (hYWHAZ) PRO 17287208
PR:000044814 (hCSF2RB/iso:1/Phos:1) Interaction PR:P63104 (hYWHAZ) PRO 10477722
PR:P63104 (hYWHAZ) Interaction PR:000044814 (hCSF2RB/iso:1/Phos:1) PRO 10477722