Protein Information

Cytoscape View


UniProt AC / UniProt ID P63092 / GNAS2_HUMAN
Protein Name Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Gene Name Name: GNAS
Synonyms:GNAS1,GSP;
Organism Homo sapiens (Human)

PRO ID PR:P63092
DAG View
PRO Name guanine nucleotide-binding protein G(s) subunit alpha isoforms Gnas-1/Gnas-2/3/4 (human)
Definition A guanine nucleotide-binding protein G(s) subunit alpha (human), isoforms Gnas-1, Gnas-2, 3, and 4.
Short Label hGNAS/iso:[Gnas-1/Gnas-2/3/4]
Category organism-seqgroup

Interactive Sequence View

Select/align proteoforms across species


P63092 (GNAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
Y311 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
R347 Methylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y358 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
Y391 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S349 Phosphorylation HPRD 20068231
S352 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K74 Ubiquitination PhosphoSitePlus
S335 Phosphorylation HPRD 20068231
S338 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K73 Ubiquitination PhosphoSitePlus
S334 Phosphorylation HPRD 20068231
S337 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S350 Phosphorylation HPRD 20068231
S353 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S51 F51 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K58 N58 Biomuta DOID:3571 / liver cancer [ icgc ]
K181 N181 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K186 N186 Biomuta DOID:3571 / liver cancer [ icgc ]
K211 N211 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K274 N274 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K338 N338 Biomuta DOID:1909 / melanoma [ cosmic ]
R347 M347 Biomuta DOID:363 / uterine cancer [ tcga ]