Protein Information

Cytoscape View


UniProt AC / UniProt ID P63085 / MK01_MOUSE
Protein Name Mitogen-activated protein kinase 1
Gene Name Name: Mapk1
Synonyms:Erk2,Mapk,Prkm1;
Organism Mus musculus (Mouse)

PRO ID PR:P63085
DAG View
PRO Name mitogen-activated protein kinase 1 (mouse)
Definition A mitogen-activated protein kinase 1 that is encoded in the genome of mouse.
Short Label mMAPK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63085 (Mapk1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C63 S-Nitrosylation dbSNO 20925432
K149 Ubiquitination PhosphoSitePlus
C159 S-Nitrosylation dbSNO 19483679, 19101475, 22178444
C164 S-Nitrosylation dbSNO 21278135
T179 Phosphorylation PhosphoSitePlus
T183 Phosphorylation P31938 (Map2k1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 1849075, 10593929, 17947660, ...21183079, 26658610, 17242355, 19131326, 18034455, 12167697
Y185 Phosphorylation P63085 (Mapk1) , P31938 (Map2k1) , P06240 (Lck) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 1849075, 1378617, 17947660, ...21183079, 10593929, 26658610, 17242355, 19131326, 7504457, 18034455, 1311128, 12167697
T188 Phosphorylation PhosphoSitePlus   RLIMS-P 19060905, 31052420, 26658610
K201 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T183 Phosphorylation PRO 12223545, 15314156, 14744933, ...11726647, 12925581, 8626447, 11684667, 16251435, 15284227
Y185 Phosphorylation PRO 12223545, 15314156, 14744933, ...11726647, 12925581, 8626447, 11684667, 16251435, 15284227


P63085 (Mapk1) as PTM Enzyme



Substrate Site Score Source PMID
A2APB8 (Tpx2) T369 PhosphoSitePlus 22028470
A6H8H2 (Dennd4c) S1221 PhosphoSitePlus 22028470
D3YXK2 (Safb) S366 PhosphoSitePlus 22028470
E9PVP1 (Crybg1) T655 PhosphoSitePlus 22028470
E9Q616 (Ahnak) S217 PhosphoSitePlus 22028470
E9Q616 (Ahnak) T695 PhosphoSitePlus 22028470
E9Q616 (Ahnak) S2985 PhosphoSitePlus 22028470
E9Q616 (Ahnak) S4879 PhosphoSitePlus 22028470
E9Q616 (Ahnak) S4890 PhosphoSitePlus 22028470
E9Q616 (Ahnak) S4906 PhosphoSitePlus 22028470
E9Q616 (Ahnak) T5567 PhosphoSitePlus 22028470
F2Z3U3 (Raph1) S611 PhosphoSitePlus 22028470
F2Z3U3 (Raph1) T879 PhosphoSitePlus 22028470
F6ZDS4 (Tpr) T2184 PhosphoSitePlus 22028470
F6ZDS4 (Tpr) T2205 PhosphoSitePlus 22028470
F6ZDS4 (Tpr) S2223 PhosphoSitePlus 22028470
O08537 (Esr2) S87 PhosphoSitePlus 10230404
O08537 (Esr2) S105 PhosphoSitePlus 10230404
O35737 (Hnrnph1) S104 PhosphoSitePlus 22028470
O35740 (Cited2) T166 RLIMS-P+ 23082118
O54819 (Tfpi) S210 PhosphoSitePlus 22028470
O54918 (Bcl2l11) S55 PhosphoSitePlus 15486085
O54918 (Bcl2l11) S65 PhosphoSitePlus 17105963, 15486085
O54918 (Bcl2l11) S100 PhosphoSitePlus 15486085
O54918 (Bcl2l11) T112 PhosphoSitePlus 18498746
O55098 (Stk10) T950 PhosphoSitePlus 22028470
O55201 (Supt5h) S664 PhosphoSitePlus 22028470
O70475 (Ugdh) T474 PhosphoSitePlus 22028470
O88286 (Wiz) S1016 PhosphoSitePlus 22028470
O88487 (Dync1i2) S81 PhosphoSitePlus 22028470
P05627 (Jun) S246 PhosphoSitePlus 12881422
P09450 (Junb) S256 PhosphoSitePlus 23712012
P10417 (Bcl2) S70 PhosphoSitePlus 10677502
P10493 (Nid1) S331 PhosphoSitePlus 22028470
P11881 (Itpr1) S436 phospho.ELM 16925983
P11881 (Itpr1) S1765 phospho.ELM 16925983
P14873 (Map1b) T1784 PhosphoSitePlus 22028470
P15037 (Ets2) T72 phospho.ELM   PhosphoSitePlus 9710599
P15806 (Tcf3) T353 Signor 14592976
P16951 (Atf2) T53 PhosphoSitePlus 16601071
P17679 (Gata1) S26 PhosphoSitePlus 15967790
P18653 (Rps6ka1) S369 PhosphoSitePlus 22698694
P20444 (Prkca) T638 PhosphoSitePlus 20513439
P22893 (Zfp36) S220 Signor 7768935
P23242 (Gja1) S255 PhosphoSitePlus 22028470
P24529 (Th) S31 PhosphoSitePlus 15447670
P25118 (Tnfrsf1a) T265 phospho.ELM   PhosphoSitePlus 10702263
P25118 (Tnfrsf1a) S269 phospho.ELM   PhosphoSitePlus 10702263
P25118 (Tnfrsf1a) S273 phospho.ELM   PhosphoSitePlus 10702263
P25118 (Tnfrsf1a) S299 phospho.ELM   PhosphoSitePlus 10702263
P26645 (Marcks) S113 RLIMS-P+ 8849678
P27577 (Ets1) T38 RLIMS-P+ 8761310
P28033 (Cebpb) T188 phospho.ELM   PhosphoSitePlus 15367685, 17601773, 17264204, ...18339625
P31938 (Map2k1) T292 PhosphoSitePlus 8013650
P31938 (Map2k1) T386 PhosphoSitePlus 8013650
P33242 (Nr5a1) S203 phospho.ELM   PhosphoSitePlus 12242296, 10230405
P34152-3 (Ptk2) S910 PhosphoSitePlus 12692126
P35569 (Irs1) S612 PhosphoSitePlus   Signor 9395471, 14579029
P35569 (Irs1) S632 Signor 14579029
P35569 (Irs1) S731 Signor 14579029
P35639 (Ddit3) S78 phospho.ELM 8650547
P41969 (Elk1) S325 Signor 7889942
P41969 (Elk1) T337 Signor 7889942
P41969 (Elk1) S384 phospho.ELM   PhosphoSitePlus   Signor 18086672, 18160653, 7889942
P41969 (Elk1) S390 phospho.ELM   Signor 7889942
P41969 (Elk1) S423 Signor 7889942
P42225 (Stat1) S727 PhosphoSitePlus 18378670
P47713 (Pla2g4a) S505 phospho.ELM   PhosphoSitePlus 8381049
P48678 (Lmna) S22 PhosphoSitePlus 22028470
P49138 (Mapkapk2) T320 PhosphoSitePlus 22028470
P54227 (Stmn1) S25 PhosphoSitePlus 22698694, 22028470, 19688729
P54227 (Stmn1) S38 PhosphoSitePlus 22028470
P58468 (Fam207a) S38 PhosphoSitePlus 22028470
P58871 (Tnks1bp1) T131 PhosphoSitePlus 22028470
P58871 (Tnks1bp1) T1025 PhosphoSitePlus 22028470
P59041 (Dnajc30) T137 PhosphoSitePlus 22028470
P62908 (Rps3) T221 PhosphoSitePlus 22028470
P63085 (Mapk1) Y185 PhosphoSitePlus 1378617, 7504457
P70333 (Hnrnph2) S104 PhosphoSitePlus 22028470
P70459 (Erf) T529 PhosphoSitePlus 22028470
P81122 (Irs2) T653 PhosphoSitePlus 22028470
P97471 (Smad4) T276 phospho.ELM   PhosphoSitePlus 12801888
P97784 (Cry1) S247 phospho.ELM 15298678
P98083 (Shc1) S36 PhosphoSitePlus 15930121
Q00175 (Pgr) S294 phospho.ELM   PhosphoSitePlus 12529413
Q01279 (Egfr) T695 PhosphoSitePlus 22028470
Q08369 (Gata4) S105 phospho.ELM   PhosphoSitePlus 11585926
Q0VGT2 (Gli2) T885 PhosphoSitePlus 22028470
Q0VGY8 (Tanc1) S1561 PhosphoSitePlus 22028470
Q3UGS4 (Mcrip1) T30 PhosphoSitePlus 22028470
Q3URZ6 (Ahnak2) T510 PhosphoSitePlus 22028470
Q60592 (Mast2) S1337 PhosphoSitePlus 22028470
Q60749 (Khdrbs1) S58 phospho.ELM   PhosphoSitePlus 12478298
Q60749 (Khdrbs1) T71 phospho.ELM   PhosphoSitePlus 12478298
Q60749 (Khdrbs1) T84 phospho.ELM   PhosphoSitePlus 12478298
Q60867 (Neurod1) S162 phospho.ELM 12810726
Q60867 (Neurod1) S259 phospho.ELM 12810726
Q60867 (Neurod1) S266 phospho.ELM 12810726
Q60867 (Neurod1) S274 phospho.ELM 12810726
Q61037 (Tsc2) S540 Signor 15851026
Q61097 (Ksr1) T260 phospho.ELM   PhosphoSitePlus 22028470, 9858547
Q61097 (Ksr1) T274 phospho.ELM   PhosphoSitePlus 9858547
Q61097 (Ksr1) S443 phospho.ELM   PhosphoSitePlus 9858547
Q61818 (Rai1) T1051 PhosphoSitePlus 22028470
Q62219 (Tgfb1i1) S141 PhosphoSitePlus 22028470
Q640N1 (Aebp1) T1003 PhosphoSitePlus 15654748
Q68FE6 (Ripor1) T351 PhosphoSitePlus 22028470
Q6A065 (Cep170) T562 PhosphoSitePlus 22028470
Q6PDH0 (Phldb1) S445 PhosphoSitePlus 22028470
Q6PDH0 (Phldb1) S463 PhosphoSitePlus 22028470
Q6R891 (Ppp1r9b) S15 phospho.ELM   PhosphoSitePlus 15728359
Q6R891 (Ppp1r9b) S205 phospho.ELM   PhosphoSitePlus 15728359
Q6Y7W8 (Gigyf2) S30 PhosphoSitePlus 22028470
Q6ZQ58 (Larp1) T278 PhosphoSitePlus 22028470
Q6ZQ58 (Larp1) S751 PhosphoSitePlus 22028470
Q70E20 (Sned1) T1239 PhosphoSitePlus 22028470
Q7TPV4 (Mybbp1a) S1280 PhosphoSitePlus 22028470
Q7TSC1 (Prrc2a) T609 PhosphoSitePlus 22028470
Q7TSC1 (Prrc2a) S1002 PhosphoSitePlus 22028470
Q7TSC1 (Prrc2a) S1217 PhosphoSitePlus 22028470
Q7TT28 (Rexo1) T259 PhosphoSitePlus 22028470
Q80U35 (Arhgef17) T695 PhosphoSitePlus 22028470
Q80U49 (Cep170b) T529 PhosphoSitePlus 22028470
Q80U49 (Cep170b) T968 PhosphoSitePlus 22028470
Q80WR0 (Nup153) T610 PhosphoSitePlus 22028470
Q80X50 (Ubap2l) T864 PhosphoSitePlus 22028470
Q80XK6 (Atg2b) T398 PhosphoSitePlus 22028470
Q80YD1 (Supv3l1) S725 PhosphoSitePlus 22028470
Q80YR5 (Safb2) S387 PhosphoSitePlus 22028470
Q80YV2 (Zc3hc1) S353 PhosphoSitePlus 22955283
Q80YV2 (Zc3hc1) S358 PhosphoSitePlus 22955283
Q811L6 (Mast4) S1436 PhosphoSitePlus 22028470
Q8BP71 (Rbfox2) T65 PhosphoSitePlus 22028470
Q8BUR4 (Dock1) T1772 PhosphoSitePlus 22028470
Q8C3Q9 (Casp9) T163 Signor 16888006
Q8CG79 (Tp53bp2) T585 PhosphoSitePlus 22028470
Q8CJ00 (Noxa1) Y252 PhosphoSitePlus 20230789
Q8CJF7 (Ahctf1) T1954 PhosphoSitePlus 22028470
Q8JZX9 (Cdc42ep2) S101 PhosphoSitePlus 22028470
Q8K0F1 (Tbc1d23) T514 PhosphoSitePlus 22028470
Q8K120 (Nfatc4) S676 PhosphoSitePlus 18086672
Q8K2J7 (Rell1) T262 PhosphoSitePlus 22028470
Q8K4R9 (Dlgap5) S328 PhosphoSitePlus 22028470
Q8R080 (Gtse1) S460 PhosphoSitePlus 22028470
Q8R1Q8 (Dync1li1) S516 PhosphoSitePlus 22028470
Q8R4Z4 (Etv3) S139 PhosphoSitePlus 22028470
Q91VX2 (Ubap2) T964 PhosphoSitePlus 22028470
Q91W92 (Cdc42ep1) S113 PhosphoSitePlus 22028470
Q91YD3 (Dcp1a) S335 PhosphoSitePlus 23637887
Q91YD3 (Dcp1a) S339 PhosphoSitePlus 23637887
Q99K01 (Pdxdc1) T691 PhosphoSitePlus 22028470
Q99N57 (Raf1) S29 Signor 15664191
Q99N57 (Raf1) S43 Signor 15664191
Q99N57 (Raf1) S289 Signor 15664191
Q99N57 (Raf1) S296 Signor 15664191
Q99N57 (Raf1) S301 Signor 15664191
Q99N57 (Raf1) S642 Signor 15664191
Q99P72 (Rtn4) T156 PhosphoSitePlus 22028470
Q9CWK8 (Snx2) T104 PhosphoSitePlus 22028470
Q9D032 (Ssbp3) T360 PhosphoSitePlus 22028470
Q9DBR1 (Xrn2) T439 PhosphoSitePlus 22028470
Q9EP71 (Rai14) T249 PhosphoSitePlus 22028470
Q9EQQ9 (Oga) T709 PhosphoSitePlus 22028470
Q9ERR1 (Ndel1) T219 PhosphoSitePlus 18331715
Q9EST3 (Eif4enif1) S114 PhosphoSitePlus 22028470
Q9JHG6 (Rcan1) S112 PhosphoSitePlus   Signor 12063245
Q9QY06 (Myo9b) T1317 PhosphoSitePlus 22028470
Q9QYR6 (Map1a) T1806 PhosphoSitePlus 22028470
Q9QYR6 (Map1a) T2182 PhosphoSitePlus 22028470
Q9QZL0 (Ripk3) T399 PhosphoSitePlus 22028470
Q9R194 (Cry2) S265 phospho.ELM 15298678
Q9R1E0 (Foxo1) S246 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) S284 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) S295 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) S326 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) S413 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) S415 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) S429 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) S467 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) S475 PhosphoSitePlus 17113751
Q9R1E0 (Foxo1) T557 PhosphoSitePlus 17113751
Q9R1L5 (Mast1) S1260 PhosphoSitePlus 22028470
Q9R1Z8 (Sorbs3) S594 phospho.ELM 15184391
Q9R1Z8 (Sorbs3) T648 PhosphoSitePlus 22028470
Q9WTQ5 (Akap12) S273 PhosphoSitePlus 22028470
Q9WTU0 (Phf2) S651 PhosphoSitePlus 22028470
Q9WU42 (Ncor2) T1718 PhosphoSitePlus 22028470
Q9WVB0-2 (Rbpms) T118 PhosphoSitePlus 22028470
Q9Z0V2 (Kcnd2) S616 PhosphoSitePlus 16600858, 18045912


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036464 (mMAPK1/iso:1/Phos:1) pT183,pY185 PRO 11684667, 11726647, 12223545, ...12925581, 14744933, 15284227, 15314156, 16251435, 8626447