iPTMnet Report for P63010 (AP2B1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P63010 / AP2B1_HUMAN
Protein Name AP-2 complex subunit beta
Gene Name Name: AP2B1
Synonyms:ADTB2,CLAPB1;
Organism Homo sapiens (Human)

PRO ID PR:P63010
DAG View
PRO Name AP-2 complex subunit beta (human)
Definition An AP-2 complex subunit beta that is encoded in the genome of human.
Short Label hAP2B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63010 (AP2B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 22814378
T2 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
K5 Ubiquitination PhosphoSitePlus
Y6 Phosphorylation phospho.ELM   PhosphoSitePlus 12900408
K11 Ubiquitination PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K19 Acetylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
C57 Methylation IEDB 31844290
S90 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
R138 Methylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
C225 Methylation IEDB 31844290
T245 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
K265 Acetylation PhosphoSitePlus   UniProt 19608861
K272 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
K318 Acetylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
Y524 Phosphorylation PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
C565 Methylation IEDB 31844290
Y574 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
S671 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 32119511, 28510447
S672 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 32119511, 28510447
S680 Phosphorylation PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
Y737 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18083107, 17456551, 18938240
R834 Methylation PhosphoSitePlus
T840 Phosphorylation PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
Y874 Phosphorylation PhosphoSitePlus
K878 Ubiquitination PhosphoSitePlus
Y888 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S890 Phosphorylation PhosphoSitePlus
K917 Ubiquitination PhosphoSitePlus
Y926 Phosphorylation PhosphoSitePlus
Y928 Phosphorylation PhosphoSitePlus
S933 Phosphorylation IEDB 35494241
Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation HPRD 19901323, 18691976
S4 Phosphorylation HPRD 18691976
Y6 Phosphorylation HPRD 19901323
S79 Phosphorylation HPRD 20068231
Y361 Phosphorylation HPRD 20068231
S497 Phosphorylation HPRD 18691976
S680 Phosphorylation HPRD 20058876
Y737 Phosphorylation HPRD 15592455, 18083107
Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation HPRD 19901323, 18691976
S4 Phosphorylation HPRD 18691976
Y6 Phosphorylation HPRD 19901323
S79 Phosphorylation HPRD 20068231
Y361 Phosphorylation HPRD 20068231
S497 Phosphorylation HPRD 18691976
S694 Phosphorylation HPRD 20058876
Y751 Phosphorylation HPRD 15592455, 18083107


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:P63010 (hAP2B1) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K11 Q11 Biomuta DOID:263 / kidney cancer [ cosmic ]
R138 Q138 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S497 L497 Biomuta DOID:4362 / cervical cancer [ cosmic, cosmic ]