iPTMnet Report for P62995 (TRA2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62995 / TRA2B_HUMAN
Protein Name Transformer-2 protein homolog beta
Gene Name Name: TRA2B
Synonyms:SFRS10;
Organism Homo sapiens (Human)

PRO ID PR:P62995
DAG View
PRO Name transformer-2 protein homolog beta (human)
Definition A transformer-2 protein homolog beta that is encoded in the genome of human.
Short Label hTRA2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62995 (TRA2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692, 22814378, 20068231
S2 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
S4 Phosphorylation PhosphoSitePlus   UniProt 21406692
S14 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
S16 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S29 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T33 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S37 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S39 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T69 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S71 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S81 Phosphorylation PhosphoSitePlus
S83 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S85 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y86 Phosphorylation PhosphoSitePlus
S87 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S95 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S97 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S99 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S102 Phosphorylation PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus   UniProt 20068231
K140 Ubiquitination PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
R187 Methylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
T201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 17287340, 20068231
T203 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
Y207 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
R210 Methylation PhosphoSitePlus
T212 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y213 Phosphorylation PhosphoSitePlus
S215 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
S216 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
Y221 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
R224 Methylation PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
R228 Methylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
R233 Methylation PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus   UniProt 23186163
R238 Methylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
R241 Methylation PhosphoSitePlus   UniProt 24129315, 15782174
R251 Methylation PhosphoSitePlus
R256 Methylation PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
S264 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935, 16964243
S266 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935, 16964243, 18220336
Y268 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y269 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S270 Phosphorylation PhosphoSitePlus
R271 Methylation PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
S276 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S278 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19413330, 18691976, 19651622, ...17081983, 20068231
S14 Phosphorylation HPRD 19413330, 18691976, 19651622, ...19007248, 20068231
S29 Phosphorylation HPRD 17081983
T33 Phosphorylation HPRD 17081983, 20068231
S37 Phosphorylation HPRD 17081983, 20068231
S39 Phosphorylation HPRD 17081983, 20068231
Y68 Phosphorylation HPRD 17081983
T69 Phosphorylation HPRD 17081983, 20068231
S71 Phosphorylation HPRD 17081983, 20068231
S81 Phosphorylation HPRD 19651622
S83 Phosphorylation HPRD 19651622, 18669648, 20068231
S85 Phosphorylation HPRD 19651622, 18669648, 20068231
Y86 Phosphorylation HPRD 19651622
S87 Phosphorylation HPRD 19651622, 18669648, 20068231
Y90 Phosphorylation HPRD 19651622
S95 Phosphorylation HPRD 19651622, 18691976, 20068231, ...18767875
S97 Phosphorylation HPRD 17322306, 18691976, 19651622, ...20068231, 18767875
S99 Phosphorylation HPRD 17322306, 18767875, 19651622, ...20068231
S102 Phosphorylation HPRD 19651622
T103 Phosphorylation HPRD 20068231
T201 Phosphorylation HPRD 19651622, 18669648, 17287340, ...20068231
T203 Phosphorylation HPRD 19651622, 18669648, 20068231
Y207 Phosphorylation HPRD 19651622, 18669648, 17287340
T212 Phosphorylation HPRD 18669648
S215 Phosphorylation HPRD 17287340, 20068231
S216 Phosphorylation HPRD 17287340, 20068231
S264 Phosphorylation HPRD 18691976, 16964243, 15302935, ...20166139, 19415658, 20068231, 20068230
S266 Phosphorylation HPRD 18691976, 16964243, 15302935, ...20166139, 19415658, 20068231, 20068230
Y268 Phosphorylation HPRD 19415658, 20068231
Y269 Phosphorylation HPRD 20166139, 20068231
S270 Phosphorylation HPRD 20068231
S278 Phosphorylation HPRD 20068231
S280 Phosphorylation HPRD 20068231
S282 Phosphorylation HPRD 20068231
Y283 Phosphorylation HPRD 20068231
S284 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 N4 Biomuta DOID:184 / bone cancer [ cosmic ]
S16 F16 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S18 F18 Biomuta DOID:363 / uterine cancer [ icgc ]
S22 N22 Biomuta DOID:4159 / skin cancer [ cosmic ]
T103 A103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K173 * Biomuta DOID:3571 / liver cancer [ cosmic ]
R187 C187 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R187 H187 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T201 M201 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y207 D207 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y222 C222 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y226 C226 Biomuta DOID:3571 / liver cancer [ cosmic ]
R228 W228 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R233 Q233 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R233 W233 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y235 C235 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R238 K238 Biomuta DOID:4159 / skin cancer [ cosmic ]
R238 T238 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R256 G256 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
Y268 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y268 N268 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R271 H271 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S276 L276 Biomuta DOID:1324 / lung cancer [ cosmic ]
S276 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S278 F278 Biomuta DOID:4159 / skin cancer [ cosmic ]
S282 A282 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S284 L284 Biomuta DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]