iPTMnet Report for P62937 (PPIA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62937 / PPIA_HUMAN
Protein Name Peptidyl-prolyl cis-trans isomerase A
Gene Name Name: PPIA
Synonyms:CYPA;
Organism Homo sapiens (Human)

PRO ID PR:P62937
DAG View
PRO Name peptidyl-prolyl cis-trans isomerase A (human)
Definition A peptidyl-prolyl cis-trans isomerase A that is encoded in the genome of human.
Short Label hPPIA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62937 (PPIA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
V2 Acetylation UniProt 19413330, 25489052, 25944712
T5 Phosphorylation PhosphoSitePlus
S21 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 21740066, 29351928, 34019948, 35083852, 20305658, 29485866, 32119511, 28510447
S21 Phosphorylation PhosphoSitePlus
K28 Acetylation PhosphoSitePlus   UniProt 19608861
K28 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Sumoylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
K44 Acetylation PhosphoSitePlus   UniProt 19608861
K44 Sumoylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
K49 Methylation PhosphoSitePlus
K49 Sumoylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
C52 S-Nitrosylation dbSNO 26338901
T68 Phosphorylation PhosphoSitePlus
K76 Acetylation IEDB   PhosphoSitePlus   UniProt 34357683, 19608861
K76 Sumoylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y79 Phosphorylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus   UniProt 19608861
K82 Sumoylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K91 Methylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus   UniProt 20068231
S99 Phosphorylation PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K118 Sumoylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
K125 Acetylation PhosphoSitePlus   UniProt 25678563, 19608861, 20364129
K125 Methylation PhosphoSitePlus
K125 Sumoylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K131 Acetylation PhosphoSitePlus   UniProt 19608861
K131 Ubiquitination PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
K133 Sumoylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
K151 Acetylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K155 Sumoylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T157 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
C161 Methylation IEDB 31844290
C161 S-Nitrosylation dbSNO 26338901, 22126794
Site PTM Type PTM Enzyme Score Source PMID
T93 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 F21 Biomuta DOID:4159 / skin cancer [ cosmic ]
C52 Y52 Biomuta DOID:4159 / skin cancer [ cosmic ]
T116 A116 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S147 F147 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K155 Q155 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]