iPTMnet Report for P62917 (RPL8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62917 / RL8_HUMAN
Protein Name Large ribosomal subunit protein uL2
Gene Name Name: RPL8
Organism Homo sapiens (Human)

PRO ID PR:P62917
DAG View
PRO Name 60S ribosomal protein L8 (human)
Definition A 60S ribosomal protein L8 that is encoded in the genome of human.
Short Label hRPL8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62917 (RPL8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Sumoylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
R37 Methylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
R54 Methylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
C90 Methylation IEDB 31844290
C90 S-Nitrosylation dbSNO 26338901
K92 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S130 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
Y133 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
K144 Sumoylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S154 O-Glycosylation GlyGen 27655845, 30444036, 18369606, ...35138101, 32522876, 33214551, 21740066, 34019948, 35083852, 31492838, 32119511, 34725712, 22121020
K155 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K177 Sumoylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K192 Methylation PhosphoSitePlus
K234 Sumoylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
R242 Methylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K60 T60 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y89 H89 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K93 N93 Biomuta DOID:363 / uterine cancer [ icgc ]
K144 N144 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S154 Y154 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K155 N155 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]