Protein Information

Cytoscape View

UniProt AC / UniProt ID P62877 / RBX1_HUMAN
Protein Name E3 ubiquitin-protein ligase RBX1
Gene Name Name: RBX1
Organism Homo sapiens (Human)

PRO ID PR:P62877
DAG View
PRO Name E3 ubiquitin-protein ligase RBX1 (human)
Definition An E3 ubiquitin-protein ligase RBX1 that is encoded in the genome of human.
Short Label hRBX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P62877 (RBX1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...20068231
T9 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231
S11 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
T13 Phosphorylation PhosphoSitePlus
S15 Phosphorylation HPRD   PhosphoSitePlus 20068231
K19 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
R99 Methylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P62877-1 (hRBX1/iso:1) Interaction PR:Q9EQW6 (mOLIG2) PRO 11027288
PR:P62877-1 (hRBX1/iso:1) Interaction PR:Q13616-1 (hCUL1/iso:1) PRO 11961546
PR:Q13616-1 (hCUL1/iso:1) Interaction PR:P62877-1 (hRBX1/iso:1) PRO 12504026, 15537541

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 I15 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y106 C106 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]