iPTMnet Report for P62826 (RAN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62826 / RAN_HUMAN
Protein Name GTP-binding nuclear protein Ran
Gene Name Name: RAN
Synonyms:ARA24;ORFNames:OK/SW-cl.81;
Organism Homo sapiens (Human)

PRO ID PR:P62826
DAG View
PRO Name GTP-binding nuclear protein Ran (human)
Definition A GTP-binding nuclear protein Ran that is encoded in the genome of human.
Short Label hRAN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62826 (RAN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
K12 Methylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus   UniProt 23186163
T25 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
R29 Methylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus   UniProt 31075303
K37 Methylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus   UniProt 19608861
K60 Methylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K71 Acetylation PhosphoSitePlus   UniProt 19608861
K71 Sumoylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K99 Acetylation PhosphoSitePlus   UniProt 19608861
K99 Ubiquitination PhosphoSitePlus
C112 S-Nitrosylation dbSNO 19483679, 22178444, 19366988, ...18335467
C120 S-Nitrosylation dbSNO 19483679, 22178444, 19366988, ...18335467
K123 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K134 Acetylation PhosphoSitePlus   UniProt 29040603
K134 Methylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S135 Phosphorylation HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20805321, 16930555, 29040603, ...20068231
S135 Phosphorylation O96013 (PAK4) neXtProt   PhosphoSitePlus   Signor 20805321
S135 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 16930555
K141 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
Y146 Phosphorylation HPRD   PhosphoSitePlus 16497976
Y147 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 15592455, 16497976
S150 Phosphorylation PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K152 Sumoylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
Y155 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K159 Acetylation PhosphoSitePlus   UniProt 19608861
K159 Methylation PhosphoSitePlus
K159 Sumoylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P61586 (RHOA) S188 P62826 (RAN) unknown eFIP 31209254


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T32 I32 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C120 S120 Biomuta DOID:1324 / lung cancer [ cosmic ]
K127 T127 Biomuta DOID:9256 / colorectal cancer [ cosmic ]