Protein Information

Cytoscape View


UniProt AC / UniProt ID P62807 / H2B1C_HUMAN
Protein Name Histone H2B type 1-C/E/F/G/I
Gene Name Name: H2BC10
Synonyms:H2BFL,HIST1H2BC;Synonyms:H2BFH,HIST1H2BE;Synonyms:H2BFG,HIST1H2BF;Synonyms:H2BFA,HIST1H2BG;Synonyms:H2BFK,HIST1H2BI;
Organism Homo sapiens (Human)

PRO ID PR:P62807
DAG View
PRO Name histone H2B type 1-C/E/F/G/I (human)
Definition A histone H2B type 1-C/E/F/G/I that is encoded in the genome of human.
Short Label hH2BC[4/6/7/8/10]
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62807 (H2BC10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
K6 Acetylation PRO   UniProt 18552846, 16283522, 16627869
S7 Phosphorylation HPRD 19413330
K12 Acetylation PhosphoSitePlus   UniProt 16627869
K13 Acetylation PRO   UniProt 18552846, 16283522, 20693536, ...16627869
S15 Phosphorylation phospho.ELM   PRO   UniProt 12757711, 1137958
K16 Acetylation PRO   PhosphoSitePlus   UniProt 16283522, 19883641, 16627869
K17 Acetylation PRO   UniProt 20693536, 16627869
K21 Acetylation PRO   UniProt 18552846, 16627869, 16283522
K24 Acetylation PhosphoSitePlus
S33 Phosphorylation phospho.ELM 192223
K35 Ubiquitination UniProt 21726816
S37 Phosphorylation phospho.ELM 192223
K47 Acetylation PRO 20693536
K47 Methylation UniProt 16627869
S56 Phosphorylation PhosphoSitePlus
K58 Methylation UniProt 16627869
K109 Methylation UniProt 16627869
S113 O-Glycosylation GlyGen   UniProt 22121020
K121 Acetylation PRO 18552846
K121 Ubiquitination PRO   UniProt 18400894, 16307923, 16627869, ...22121020, 19575011, 16713563, 18923072, 18832071


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036257 (hH2BC[4/6/7/8/10]/Ac:1) acM1 PRO
PR:000045035 (hH2BC[4/6/7/8/10]/InitMet-/Ac:1) acK13 PRO 16283522, 18552846, 20693536
PR:000045036 (hH2BC[4/6/7/8/10]/InitMet-/Phos:1) pS15 PRO 12757711
PR:000045037 (hH2BC[4/6/7/8/10]/InitMet-/Ac:2) acK21 PRO 16283522, 18552846
PR:000045039 (hH2BC[4/6/7/8/10]/InitMet-/Ubiq:1) ubK121 PRO 16307923, 16713563, 18400894, ...18832071, 18923072, 19575011
PR:000045040 (hH2BC[4/6/7/8/10]/InitMet-/Ac:3) acK17 PRO 20693536
PR:000045041 (hH2BC[4/6/7/8/10]/InitMet-/Ac:4) acK6 PRO 18552846
PR:000045043 (hH2BC[4/6/7/8/10]/InitMet-/Ac:5) acK47 PRO 20693536
PR:000045044 (hH2BC[4/6/7/8/10]/InitMet-/Ac:6) acK121 PRO 18552846
PR:000045045 (hH2BC[4/6/7/8/10]/InitMet-/Ac:7) acK16 PRO 19883641


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:8618 / oral cavity cancer [ icgc ] DOID:10534 / stomach cancer [ icgc ] DOID:9256 / colorectal cancer [ tcga ]
K6 N6 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S7 F7 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S7 C7 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
S7 P7 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K12 N12 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K12 R12 Biomuta DOID:1324 / lung cancer [ cosmic ]
K13 N13 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K13 M13 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
K13 R13 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S15 T15 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K16 N16 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K17 N17 Biomuta DOID:1324 / lung cancer [ cosmic ]
K17 E17 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K24 N24 Biomuta DOID:1612 / breast cancer [ cosmic ]
K35 E35 Biomuta DOID:0070003 / blastoma [ cosmic ]
K35 R35 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S37 N37 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S37 R37 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S37 T37 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K47 * Biomuta DOID:1324 / lung cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S56 L56 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:3963 / thyroid carcinoma [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
K58 Q58 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K58 E58 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K109 N109 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S113 L113 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]