Protein Information

Cytoscape View


UniProt AC / UniProt ID P62807 / H2B1C_HUMAN
Protein Name Histone H2B type 1-C/E/F/G/I
Gene Name Name: H2BC10
Synonyms:H2BFL,HIST1H2BC;Synonyms:H2BFH,HIST1H2BE;Synonyms:H2BFG,HIST1H2BF;Synonyms:H2BFA,HIST1H2BG;Synonyms:H2BFK,HIST1H2BI;
Organism Homo sapiens (Human)

PRO ID PR:P62807
DAG View
PRO Name histone H2B type 1-C/E/F/G/I (human)
Definition A histone H2B type 1-C/E/F/G/I that is encoded in the genome of human.
Short Label hHIST1H2B[C/E/F/G/I]
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62807 (H2BC10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
K6 Acetylation PRO   PhosphoSitePlus   UniProt 18552846, 16283522, 16627869
K6 Methylation PhosphoSitePlus
K6 Sumoylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
S7 Phosphorylation HPRD   PhosphoSitePlus 19413330
K12 Acetylation PhosphoSitePlus   UniProt 16627869
K13 Acetylation PRO   PhosphoSitePlus   UniProt 18552846, 16283522, 20693536, ...16627869
S15 Phosphorylation phospho.ELM   PRO   UniProt 12757711, 1137958
K16 Acetylation PRO   PhosphoSitePlus   UniProt 16283522, 19883641, 16627869
K17 Acetylation PRO   PhosphoSitePlus   UniProt 20693536, 16627869
K21 Acetylation PRO   PhosphoSitePlus   UniProt 18552846, 16627869, 16283522
K21 Methylation PhosphoSitePlus
K21 Sumoylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
S33 Phosphorylation phospho.ELM   PhosphoSitePlus 192223
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus   UniProt 21726816
S37 Phosphorylation phospho.ELM   PhosphoSitePlus 192223
Y38 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
K44 Acetylation PhosphoSitePlus
K44 Methylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K47 Acetylation PRO   PhosphoSitePlus 20693536
K47 Methylation UniProt 16627869
K47 Sumoylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
K58 Methylation UniProt 16627869
K58 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
R80 Methylation PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
R87 Methylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
R93 Methylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
R100 Methylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Methylation UniProt 16627869
K109 Sumoylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S113 O-Glycosylation UniProt 22121020
S113 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
K117 Sumoylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
K121 Acetylation PRO   PhosphoSitePlus 18552846
K121 Sumoylation PhosphoSitePlus
K121 Ubiquitination PRO   PhosphoSitePlus   UniProt 18400894, 16307923, 16627869, ...22121020, 19575011, 16713563, 18923072, 18832071
T123 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036257 (hHIST1H2B[C/E/F/G/I]/Ac:1) acM1 PRO
PR:000045035 (hHIST1H2B[C/E/F/G/I]/InitMet-/Ac:1) acK13 PRO 16283522, 18552846, 20693536
PR:000045036 (hHIST1H2B[C/E/F/G/I]/InitMet-/Phos:1) pS15 PRO 12757711
PR:000045037 (hHIST1H2B[C/E/F/G/I]/InitMet-/Ac:2) acK21 PRO 16283522, 18552846
PR:000045039 (hHIST1H2B[C/E/F/G/I]/InitMet-/Ubiq:1) ubK121 PRO 16307923, 16713563, 18400894, ...18832071, 18923072, 19575011
PR:000045040 (hHIST1H2B[C/E/F/G/I]/InitMet-/Ac:3) acK17 PRO 20693536
PR:000045041 (hHIST1H2B[C/E/F/G/I]/InitMet-/Ac:4) acK6 PRO 18552846
PR:000045043 (hHIST1H2B[C/E/F/G/I]/InitMet-/Ac:5) acK47 PRO 20693536
PR:000045044 (hHIST1H2B[C/E/F/G/I]/InitMet-/Ac:6) acK121 PRO 18552846
PR:000045045 (hHIST1H2B[C/E/F/G/I]/InitMet-/Ac:7) acK16 PRO 19883641


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:8618 / oral cavity cancer [ icgc ] DOID:10534 / stomach cancer [ icgc ] DOID:9256 / colorectal cancer [ tcga ]
K6 N6 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S7 F7 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S7 C7 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
S7 P7 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K12 N12 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K12 R12 Biomuta DOID:1324 / lung cancer [ cosmic ]
K13 N13 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K13 M13 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
K13 R13 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S15 T15 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K16 N16 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K17 N17 Biomuta DOID:1324 / lung cancer [ cosmic ]
K17 E17 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K24 N24 Biomuta DOID:1612 / breast cancer [ cosmic ]
K25 Q25 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K35 E35 Biomuta DOID:0070003 / blastoma [ cosmic ]
K35 R35 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S37 R37 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S37 T37 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S37 N37 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y41 * Biomuta DOID:1324 / lung cancer [ tcga ]
Y41 H41 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y41 F41 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y43 F43 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
Y43 C43 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y43 * Biomuta DOID:1909 / melanoma [ cosmic ]
K44 R44 Biomuta DOID:10534 / stomach cancer [ tcga ]
K47 * Biomuta DOID:1324 / lung cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
T53 I53 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:2531 / hematologic cancer [ icgc ]
S56 L56 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:3963 / thyroid carcinoma [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
S57 Y57 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S57 T57 Biomuta DOID:1324 / lung cancer [ tcga ]
S57 C57 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S57 F57 Biomuta DOID:1324 / lung cancer [ tcga ]
K58 E58 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K58 Q58 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S65 F65 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S65 C65 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S65 A65 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S65 Y65 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:169 / neuroendocrine tumor [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
R73 C73 Biomuta DOID:4362 / cervical cancer [ cosmic, tcga ] DOID:2531 / hematologic cancer [ icgc ]
R73 G73 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R73 S73 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ tcga ]
R73 H73 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:2531 / hematologic cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
S79 F79 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:1909 / melanoma [ icgc, tcga ]
R80 C80 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ] DOID:0070003 / blastoma [ cosmic ]
Y84 * Biomuta DOID:1612 / breast cancer [ tcga ]
K86 M86 Biomuta DOID:363 / uterine cancer [ tcga ]
K86 N86 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R87 C87 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S88 W88 Biomuta DOID:1324 / lung cancer [ tcga ]
S88 A88 Biomuta DOID:1324 / lung cancer [ tcga ]
S88 L88 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T89 A89 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T89 N89 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T89 S89 Biomuta DOID:2994 / germ cell cancer [ cosmic ] DOID:11934 / head and neck cancer [ tcga ]
T91 A91 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S92 F92 Biomuta DOID:3070 / malignant glioma [ tcga ]
S92 C92 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R93 M93 Biomuta DOID:1324 / lung cancer [ tcga ]
R93 S93 Biomuta DOID:1324 / lung cancer [ tcga ]
R93 G93 Biomuta DOID:1324 / lung cancer [ tcga ]
T97 S97 Biomuta DOID:10534 / stomach cancer [ tcga ]
T97 A97 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R100 H100 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R100 C100 Biomuta DOID:2994 / germ cell cancer [ tcga ]
K109 N109 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S113 L113 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K117 E117 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T120 N120 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T120 I120 Biomuta DOID:2531 / hematologic cancer [ icgc, tcga ]
T123 R123 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T123 S123 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T123 A123 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ icgc, tcga ]
T123 I123 Biomuta DOID:263 / kidney cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ]
S124 N124 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S124 R124 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K126 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]