Protein Information

Cytoscape View


UniProt AC / UniProt ID P62753 / RS6_HUMAN
Protein Name 40S ribosomal protein S6
Gene Name Name: RPS6
ORFNames:OK/SW-cl.2;
Organism Homo sapiens (Human)

PRO ID PR:P62753
DAG View
PRO Name 40S ribosomal protein S6 (human)
Definition A 40S ribosomal protein S6 that is encoded in the genome of human.
Short Label hRPS6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62753 (RPS6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Methylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus   RLIMS-P 27105488, 33471625, 24425783, ...29487290, 29207653, 26259639, 20190034, 22028912, 31287628, 30698812, 19648476, 22929805
C12 S-Nitrosylation dbSNO 19483679, 2212679, 22126794, ...26338901
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
R22 Methylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
Y28 Phosphorylation PhosphoSitePlus
K30 Acetylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
S78 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K79 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
K143 Acetylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S148 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K149 Ubiquitination PhosphoSitePlus
R154 Methylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
K211 Acetylation PhosphoSitePlus   UniProt 19608861
K211 Ubiquitination PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
S235 Phosphorylation HPRD   IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15358595, 25993328, 30902093, ...33371356, 32612497, 32188029, 23186163, 17360704, 21437771, 15471950, 26490682, 33149163, 19376132, 18974095, 15956968, 30698812, 3461469, 18767875, 24072592, 21418524, 27487136, 17081983, 23974852, 17087515, 16083285, 17287340, 31910234, 28247844, 29487290, 20460585, 17322306, 18669648, 1737763, 28603468
S235 Phosphorylation P23443 (RPS6KB1) neXtProt   PhosphoSitePlus 17360704, 1737763
S235 Phosphorylation P51812 (RPS6KA3) neXtProt   PhosphoSitePlus 17360704
S235 Phosphorylation P53355 (DAPK1) neXtProt 17087515
S235 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 15471950
S235 Phosphorylation Q13177 (PAK2) HPRD 17322306, 18767875, 18669648, ...17287340
S235 Phosphorylation Q15418 (RPS6KA1) neXtProt   PhosphoSitePlus   Signor 17360704
S235 Phosphorylation Q96RG2 (PASK) neXtProt 21418524
S236 Phosphorylation HPRD   IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25993328, 30902093, 33371356, ...32612497, 32188029, 17081983, 21406692, 23186163, 17360704, 21437771, 15471950, 26490682, 33149163, 19376132, 18974095, 15956968, 30698812, 18767875, 24072592, 21418524, 27487136, 15358595, 23974852, 16083285, 17287340, 31910234, 28247844, 29487290, 20460585, 17322306, 18669648, 1737763, 1939282, 28603468
S236 Phosphorylation P23443 (RPS6KB1) neXtProt   PhosphoSitePlus 17360704, 1737763
S236 Phosphorylation P51812 (RPS6KA3) neXtProt   PhosphoSitePlus 17360704
S236 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 15471950
S236 Phosphorylation Q13177 (PAK2) HPRD 17322306, 18767875, 18669648, ...17287340
S236 Phosphorylation Q15418 (RPS6KA1) neXtProt   PhosphoSitePlus   Signor 17360704
S236 Phosphorylation Q96RG2 (PASK) neXtProt 21418524
S240 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8440735, 21406692, 16083285, ...17287340, 17081983, 28978054, 17360704, 25993328, 29487290, 23643747, 19007248, 30902093, 17322306, 18669648, 1737763, 32612497, 18565837, 23186163, 21233202, 20068231
S240 Phosphorylation P23443 (RPS6KB1) neXtProt   PhosphoSitePlus 17360704, 1737763
S240 Phosphorylation Q13177 (PAK2) HPRD 17322306, 18669648, 17287340, ...19007248
S240 Phosphorylation Q15418 (RPS6KA1) Signor 21233202
T241 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S242 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 1985906
S242 Phosphorylation Q13177 (PAK2) HPRD 18669648, 1985906
S244 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8440735, 1737763, 17287340, ...23643747, 17360704, 25993328, 29487290, 28978054, 30902093, 18669648, 21233202, 32612497, 18565837
S244 Phosphorylation P23443 (RPS6KB1) neXtProt   PhosphoSitePlus 17360704, 1737763
S244 Phosphorylation Q15418 (RPS6KA1) Signor 21233202
S246 Phosphorylation PhosphoSitePlus
S247 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 8440735, 18669648, 1737763, ...24616378
S247 Phosphorylation P23443 (RPS6KB1) neXtProt 1737763


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049122 (hRPS6/Phos:1) pS235,pS236,pS240,pS244,pS247 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P62753 (RPS6) S235 Q96RG2 (PASK) unknown eFIP 21418524


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 A6 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R22 C22 Biomuta DOID:1909 / melanoma [ tcga ]
S148 F148 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K149 E149 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S236 C236 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S236 F236 Biomuta DOID:1612 / breast cancer [ tcga ]