iPTMnet Report for P62736 (ACTA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62736 / ACTA_HUMAN
Protein Name Actin, aortic smooth muscle precursor
Gene Name Name: ACTA2
Synonyms:ACTSA,ACTVS;ORFNames:GIG46;
Organism Homo sapiens (Human)

PRO ID PR:P62736
DAG View
PRO Name actin, aortic smooth muscle (human)
Definition An actin, aortic smooth muscle that is encoded in the genome of human.
Short Label hACTA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62736 (ACTA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
E3 Acetylation UniProt 22223895
R30 Methylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Methylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Sumoylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus
K70 Methylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
E74 Methylation IEDB 29786170
H75 Methylation IEDB 29786170
G76 Methylation IEDB 29786170
T79 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Methylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
R97 Methylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Methylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
R198 Methylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Methylation PhosphoSitePlus
C219 S-Nitrosylation dbSNO 21278135
Y220 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K240 Methylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
C259 S-Nitrosylation dbSNO 21278135
T262 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
T279 O-Glycosylation GlyGen 29351928
T280 O-Glycosylation GlyGen 29351928
T280 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
C287 Methylation IEDB 31844290
C287 S-Nitrosylation dbSNO 21278135
K293 Ubiquitination PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
K317 Sumoylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
S325 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983, 19664995
T326 Phosphorylation HPRD   PhosphoSitePlus 17081983
K328 Acetylation PhosphoSitePlus
K328 Methylation PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
K330 Sumoylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K338 Sumoylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
S370 O-Glycosylation GlyGen 29351928, 18369606, 30397120
S370 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
C376 S-Nitrosylation dbSNO 21278135


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
E3 K3 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R30 M30 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S35 P35 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S54 N54 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y71 C71 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
E74 * Biomuta DOID:363 / uterine cancer [ cosmic ]
E74 K74 Biomuta DOID:4159 / skin cancer [ cosmic ]
K86 N86 Biomuta DOID:363 / uterine cancer [ icgc ]
R97 C97 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
R97 H97 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K115 N115 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S157 F157 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K193 N193 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K215 N215 Biomuta DOID:363 / uterine cancer [ icgc ]
S236 F236 Biomuta DOID:4159 / skin cancer [ cosmic ]
C259 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S267 C267 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T279 N279 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K317 T317 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T320 R320 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T320 M320 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K328 N328 Biomuta DOID:1612 / breast cancer [ icgc ]
K328 T328 Biomuta DOID:5041 / esophageal cancer [ cosmic ]