iPTMnet Report for P62495 (ETF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62495 / ERF1_HUMAN
Protein Name Eukaryotic peptide chain release factor subunit 1
Gene Name Name: ETF1
Synonyms:ERF1,RF1,SUP45L1;
Organism Homo sapiens (Human)

PRO ID PR:P62495
DAG View
PRO Name eukaryotic peptide chain release factor subunit 1 (human)
Definition A eukaryotic peptide chain release factor subunit 1 that is encoded in the genome of human.
Short Label hETF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62495 (ETF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 12665801
R10 Methylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
R182 Methylation PhosphoSitePlus
Q185 Methylation UniProt 18539146, 20606008, 26797129
R189 Methylation PhosphoSitePlus
Y201 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
R289 Methylation PhosphoSitePlus
C302 Methylation IEDB 31844290
Y331 Phosphorylation PhosphoSitePlus
C335 S-Nitrosylation dbSNO 19483679
K342 Acetylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus   UniProt 23186163
K352 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
T388 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34725712, 25367160, 34019948, 28510447, 34229054
K395 Ubiquitination PhosphoSitePlus
K404 Methylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T208 Phosphorylation HPRD 20068231
S215 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R10 S10 Biomuta DOID:3571 / liver cancer [ cosmic ]
S70 L70 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K106 N106 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S141 L141 Biomuta DOID:1612 / breast cancer [ cosmic ]
S141 A141 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R182 K182 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R289 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C335 R335 Biomuta DOID:1324 / lung cancer [ cosmic ]
T347 I347 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K352 N352 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T388 M388 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]