Protein Information

Cytoscape View


UniProt AC / UniProt ID P62330 / ARF6_HUMAN
Protein Name ADP-ribosylation factor 6
Gene Name Name: ARF6
Organism Homo sapiens (Human)

PRO ID PR:P62330
DAG View
PRO Name ADP-ribosylation factor 6 (human)
Definition An ADP-ribosylation factor 6 that is encoded in the genome of human.
Short Label hARF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62330 (ARF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 7589240, 25255805
K7 Ubiquitination PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
T41 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K69 Sumoylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
C90 S-Nitrosylation dbSNO 26338901
K131 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K7 T7 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y31 H31 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K34 N34 Biomuta DOID:1324 / lung cancer [ tcga ]
K55 R55 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K69 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y150 H150 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K174 R174 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]