Protein Information

Cytoscape View


UniProt AC / UniProt ID P62258 / 1433E_HUMAN
Protein Name 14-3-3 protein epsilon
Gene Name Name: YWHAE
Organism Homo sapiens (Human)

PRO ID PR:P62258
DAG View
PRO Name 14-3-3 protein epsilon (human)
Definition A 14-3-3 protein epsilon that is encoded in the genome of human.
Short Label hYWHAE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62258 (YWHAE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
R4 Methylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus   UniProt 19608861
K50 Ubiquitination PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus   UniProt 19608861
K69 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
C97 S-Nitrosylation dbSNO 19483679, 22178444
C98 S-Nitrosylation dbSNO 19483679, 22178444
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus   UniProt 19608861
K118 Ubiquitination PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus   UniProt 19608861
K123 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
R130 Methylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
K153 Methylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
T208 Phosphorylation Q9NYY3 (PLK2) , Q9H4B4 (PLK3) PhosphoSitePlus 22828320
S210 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S213 Phosphorylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus   UniProt 24275569
S233 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
T38 Phosphorylation HPRD 19413330
S46 Phosphorylation HPRD 20068231
K50 Acetylation PRO
S64 Phosphorylation HPRD 20068231
S65 Phosphorylation HPRD 20068231
K69 Acetylation PRO
T91 Phosphorylation HPRD 20068231
S210 Phosphorylation HPRD 19413330, 20058876, 19664994, ...18452278, 19651622, 20166139, 20068231
S213 Phosphorylation HPRD 20068231
S217 Phosphorylation HPRD 20068231
T218 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036162 (hYWHAE/iso:1/Ac:1) acM1 PRO
PR:000044852 (hYWHAE/iso:1/Ac:2) acM1,acK50,acK69 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q00613 (HSF1) S307 P62258 (YWHAE) unknown eFIP 12917326
Phosphorylation Q00613 (HSF1) S303 P62258 (YWHAE) unknown eFIP 12917326


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025725 (hHSF1/iso:Long/Phos:2) Interaction PR:P62258 (hYWHAE) PRO 12917326
PR:000025725 (hHSF1/iso:Long/Phos:2) Interaction PR:P62258 (hYWHAE) PRO 12917326
PR:000025725 (hHSF1/iso:Long/Phos:2) Interaction PR:P62258 (hYWHAE) PRO 12917326
PR:000026167 (mBAD/iso:1/Phos:1) Interaction PR:P62258-1 (hYWHAE/iso:1) PRO 10490655
PR:000026167 (mBAD/iso:1/Phos:1) Interaction PR:P62258-1 (hYWHAE/iso:1) PRO 10490655
PR:000026167 (mBAD/iso:1/Phos:1) Interaction PR:P62258-1 (hYWHAE/iso:1) PRO 10490655
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P62258 (hYWHAE) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P62258 (hYWHAE) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P62258 (hYWHAE) PRO 15057270
PR:P62258-1 (hYWHAE/iso:1) Interaction PR:000026167 (mBAD/iso:1/Phos:1) PRO 10949026
PR:P62258-1 (hYWHAE/iso:1) Interaction PR:000026133 (mBAD/iso:1/Phos:2) PRO 10949026
PR:P62258-1 (hYWHAE/iso:1) Interaction PR:000026167 (mBAD/iso:1/Phos:1) PRO 10949026
PR:P62258-1 (hYWHAE/iso:1) Interaction PR:000026133 (mBAD/iso:1/Phos:2) PRO 10949026
PR:P62258-1 (hYWHAE/iso:1) Interaction PR:000026167 (mBAD/iso:1/Phos:1) PRO 10949026
PR:P62258-1 (hYWHAE/iso:1) Interaction PR:000026133 (mBAD/iso:1/Phos:2) PRO 10949026


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R4 * Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
R4 Q4 Biomuta DOID:1612 / breast cancer [ icgc ]
S46 A46 Biomuta DOID:363 / uterine cancer [ tcga ]
Y49 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y49 C49 Biomuta DOID:1324 / lung cancer [ cosmic ]
K50 N50 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K50 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K80 * Biomuta DOID:9256 / colorectal cancer [ tcga ]
K125 T125 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T208 K208 Biomuta DOID:363 / uterine cancer [ tcga ]
S233 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]