iPTMnet Report for P62195 (PSMC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62195 / PRS8_HUMAN
Protein Name 26S proteasome regulatory subunit 8
Gene Name Name: PSMC5
Synonyms:SUG1;
Organism Homo sapiens (Human)

PRO ID PR:P62195
DAG View
PRO Name 26S proteasome regulatory subunit 8 (human)
Definition A 26S proteasome regulatory subunit 8 that is encoded in the genome of human.
Short Label hPSMC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62195 (PSMC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
A2 Acetylation UniProt 19413330, 25489052, 22814378, ...22223895
K15 Ubiquitination PhosphoSitePlus
R21 Methylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
N36 N-Glycosylation GlyGen 24190977
K38 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
C112 Methylation IEDB 31844290
C112 S-Nitrosylation dbSNO 26338901
S120 Phosphorylation PhosphoSitePlus   UniProt 17565987, 23186163, 23275441
S120 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 17565987, 23275441
Y121 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
C209 Methylation IEDB 31844290
S217 Phosphorylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus   UniProt 19608861
K222 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
C363 Methylation IEDB 31844290
T364 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S136 Phosphorylation HPRD 20068231
S303 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K88 N88 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S120 N120 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K130 Q130 Biomuta DOID:4159 / skin cancer [ cosmic ]
S136 P136 Biomuta DOID:363 / uterine cancer [ icgc ]
K170 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S263 Y263 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S303 L303 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K330 N330 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K330 M330 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K346 R346 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K397 E397 Biomuta DOID:363 / uterine cancer [ icgc ]
K402 N402 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]