iPTMnet Report for P62191 (PSMC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62191 / PRS4_HUMAN
Protein Name 26S proteasome regulatory subunit 4
Gene Name Name: PSMC1
Organism Homo sapiens (Human)

PRO ID PR:P62191
DAG View
PRO Name 26S proteasome regulatory subunit 4 (human)
Definition A 26S proteasome regulatory subunit 4 that is encoded in the genome of human.
Short Label hPSMC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62191 (PSMC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 22223895, 25255805, 25807930
S4 Phosphorylation PhosphoSitePlus   UniProt 19690332
S6 Phosphorylation PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
Y25 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T56 Phosphorylation PhosphoSitePlus
C58 S-Nitrosylation dbSNO 26338901
K61 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K98 Sumoylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K175 Sumoylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus   UniProt 17370265
T246 Phosphorylation PhosphoSitePlus
K258 Acetylation PhosphoSitePlus   UniProt 19608861
K258 Ubiquitination PhosphoSitePlus
K265 Acetylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
R322 Methylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
C399 Methylation IEDB 31844290
K413 Ubiquitination PhosphoSitePlus
K420 Acetylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K429 Acetylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K430 Sumoylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y439 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 18077418
T308 Phosphorylation HPRD 20058876
Y439 Phosphorylation HPRD 15144186


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 N48 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K61 Q61 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y225 C225 Biomuta DOID:4159 / skin cancer [ cosmic ]
K258 R258 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T308 A308 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K423 N423 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]