Protein Information

Cytoscape View

UniProt AC / UniProt ID P62140 / PP1B_HUMAN
Protein Name Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Gene Name Name: PPP1CB
Organism Homo sapiens (Human)

PRO ID PR:P62140
DAG View
PRO Name serine/threonine-protein phosphatase PP1-beta catalytic subunit (human)
Definition A serine/threonine-protein phosphatase PP1-beta catalytic subunit that is encoded in the genome of human.
Short Label hPPP1CB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P62140 (PPP1CB) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 12665801, 22223895
R19 Methylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
R35 Methylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
S41 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
S47 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
K59 Ubiquitination PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
R121 Methylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
R131 Methylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
K140 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
Y254 Phosphorylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K303 Acetylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
S311 Phosphorylation HPRD   PhosphoSitePlus 20068231
T316 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 18669648, ...20166139, 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R19 L19 Biomuta DOID:3571 / liver cancer [ icgc ]
K25 N25 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R35 * Biomuta DOID:363 / uterine cancer [ tcga ]
S41 Y41 Biomuta DOID:1909 / melanoma [ tcga ]
S47 I47 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R131 H131 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
Y306 * Biomuta DOID:1324 / lung cancer [ tcga ]
Y306 H306 Biomuta DOID:1793 / pancreatic cancer [ icgc ]