iPTMnet Report for P62136 (PPP1CA)
Protein Information
UniProt AC / UniProt ID | P62136 / PP1A_HUMAN |
Protein Name | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
Gene Name | Name: PPP1CA Synonyms:PPP1A; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P62136 |
PRO Name | serine/threonine-protein phosphatase PP1-alpha catalytic subunit (human) |
Definition | A serine/threonine-protein phosphatase PP1-alpha catalytic subunit that is encoded in the genome of human. |
Short Label | hPPP1CA |
Category | organism-gene |
P62136 (PPP1CA) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Acetylation | score1 | UniProt | 22814378 | ||
S2 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K6 | Ubiquitination | score1 | PhosphoSitePlus | |||
S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
S22 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
R36 | Methylation | score1 | PhosphoSitePlus | |||
C39 | Methylation | score1 | IEDB | 31844290 | ||
K41 | Ubiquitination | score1 | PhosphoSitePlus | |||
S48 | Phosphorylation | score1 | PhosphoSitePlus | |||
K60 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y93 | Phosphorylation | score1 | PhosphoSitePlus | |||
K98 | Ubiquitination | score1 | PhosphoSitePlus | |||
K113 | Acetylation | score1 | PhosphoSitePlus | |||
K113 | Ubiquitination | score1 | PhosphoSitePlus | |||
R122 | Methylation | score1 | PhosphoSitePlus | |||
S129 | Phosphorylation | score1 | PhosphoSitePlus | |||
R132 | Methylation | score1 | PhosphoSitePlus | |||
Y134 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y137 | Phosphorylation | score1 | PhosphoSitePlus | |||
K141 | Acetylation | score1 | PhosphoSitePlus | |||
K141 | Ubiquitination | score1 | PhosphoSitePlus | |||
K147 | Acetylation | score1 | PhosphoSitePlus | |||
K147 | Ubiquitination | score1 | PhosphoSitePlus | |||
K150 | Ubiquitination | score1 | PhosphoSitePlus | |||
S177 | Phosphorylation | score1 | PhosphoSitePlus | |||
K238 | Acetylation | score1 | PhosphoSitePlus | |||
K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y255 | Phosphorylation | score1 | PhosphoSitePlus | |||
K260 | Acetylation | score1 | PhosphoSitePlus | |||
K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
K305 | Acetylation | score1 | PhosphoSitePlus | |||
K305 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y306 | Phosphorylation | score1 | PhosphoSitePlus | |||
S310 | Phosphorylation | score1 | PhosphoSitePlus | |||
T320 | Phosphorylation | P24941 (CDK2) , P31749 (AKT1) , Q8IWU2 (LMTK2) , Q00535 (CDK5) , P06493 (CDK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 9197238, 21331744, 23186163, ... | |
S325 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K329 | Methylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S11 | Phosphorylation | score0 | HPRD | 20068231 | ||
S22 | Phosphorylation | score0 | HPRD | 20068231 | ||
T320 | Phosphorylation | score0 | HPRD | 18669648, 18088087, 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K6 | R6 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
C39 | Y39 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K113 | E113 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
R122 | C122 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
R132 | H132 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y137 | C137 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
K147 | I147 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
K147 | N147 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K147 | T147 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
Y255 | F255 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K260 | E260 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
Y306 | C306 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y306 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
Y306 | F306 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K329 | N329 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |