iPTMnet Report for P62136 (PPP1CA)
Protein Information
| UniProt AC / UniProt ID | P62136 / PP1A_HUMAN |
| Protein Name | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
| Gene Name | Name: PPP1CA Synonyms:PPP1A; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P62136 |
| PRO Name | serine/threonine-protein phosphatase PP1-alpha catalytic subunit (human) |
| Definition | A serine/threonine-protein phosphatase PP1-alpha catalytic subunit that is encoded in the genome of human. |
| Short Label | hPPP1CA |
| Category | organism-gene |
P62136 (PPP1CA) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S2 | Acetylation | score1 | UniProt | 22814378 | ||
| S2 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K6 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S22 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R36 | Methylation | score1 | PhosphoSitePlus | |||
| C39 | Methylation | score1 | IEDB | 31844290 | ||
| K41 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S48 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K60 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y93 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K98 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K113 | Acetylation | score1 | PhosphoSitePlus | |||
| K113 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R122 | Methylation | score1 | PhosphoSitePlus | |||
| S129 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R132 | Methylation | score1 | PhosphoSitePlus | |||
| Y134 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y137 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K141 | Acetylation | score1 | PhosphoSitePlus | |||
| K141 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K147 | Acetylation | score1 | PhosphoSitePlus | |||
| K147 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K150 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S177 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K238 | Acetylation | score1 | PhosphoSitePlus | |||
| K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y255 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K260 | Acetylation | score1 | PhosphoSitePlus | |||
| K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K305 | Acetylation | score1 | PhosphoSitePlus | |||
| K305 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y306 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S310 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T320 | Phosphorylation | P24941 (CDK2) , P31749 (AKT1) , Q8IWU2 (LMTK2) , Q00535 (CDK5) , P06493 (CDK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 9197238, 21331744, 23186163, ... | |
| S325 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K329 | Methylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S11 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S22 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T320 | Phosphorylation | score0 | HPRD | 18669648, 18088087, 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K6 | R6 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| C39 | Y39 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K113 | E113 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| R122 | C122 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
| R132 | H132 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y137 | C137 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| K147 | I147 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| K147 | N147 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K147 | T147 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y255 | F255 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K260 | E260 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y306 | C306 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y306 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| Y306 | F306 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K329 | N329 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
DAG View