iPTMnet Report for P61981 (YWHAG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61981 / 1433G_HUMAN
Protein Name 14-3-3 protein gamma
Gene Name Name: YWHAG
Organism Homo sapiens (Human)

PRO ID PR:P61981
DAG View
PRO Name 14-3-3 protein gamma (human)
Definition A 14-3-3 protein gamma that is encoded in the genome of human.
Short Label hYWHAG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61981 (YWHAG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
V2 Acetylation UniProt 19413330, 14534293
K10 Ubiquitination PhosphoSitePlus
Y20 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S46 Phosphorylation HPRD   PhosphoSitePlus 19664994
Y49 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K50 Methylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S59 Phosphorylation Q9NRM7 (LATS2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 29311810, 21118956, 25086053
S65 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S71 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K77 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
C112 Methylation IEDB 31844290
T115 Phosphorylation PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
T168 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y179 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
C194 Methylation IEDB 31844290
K198 Ubiquitination PhosphoSitePlus
T199 Phosphorylation HPRD   PhosphoSitePlus 18452278
T210 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
T220 Phosphorylation HPRD   PhosphoSitePlus 19664994
T234 Phosphorylation PhosphoSitePlus   UniProt 24275569
S235 Phosphorylation PhosphoSitePlus   UniProt 24275569


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P53350 (PLK1) S99 P61981 (YWHAG) unknown eFIP 23695676


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025837 (hMDM4/iso:1/PhosUbiq:1) Interaction PR:P61981 (hYWHAG) PRO 16511572
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P61981 (hYWHAG) PRO 15057270
PR:000044818 (hPLK1/Phos:1) Interaction PR:P61981 (hYWHAG) PRO 23695676
PR:000044819 (hPAK4/iso:1/Phos:1) Interaction PR:P61981 (hYWHAG) PRO 23695676


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S38 L38 Biomuta DOID:1324 / lung cancer [ cosmic ]
S46 C46 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S59 F59 Biomuta DOID:4159 / skin cancer [ cosmic ]
S71 Y71 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K77 R77 Biomuta DOID:4159 / skin cancer [ cosmic ]
K110 N110 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y130 C130 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y154 C154 Biomuta DOID:1324 / lung cancer [ cosmic ]
K162 I162 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K162 N162 Biomuta DOID:1324 / lung cancer [ cosmic ]
T168 A168 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S180 F180 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1725 / peritoneum cancer [ cosmic ]
T199 I199 Biomuta DOID:4159 / skin cancer [ cosmic ]
T234 A234 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]