Protein Information

Cytoscape View


UniProt AC / UniProt ID P61978 / HNRPK_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein K
Gene Name Name: HNRNPK
Synonyms:HNRPK;
Organism Homo sapiens (Human)

PRO ID PR:P61978
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein K (human)
Definition A heterogeneous nuclear ribonucleoprotein K that is encoded in the genome of human.
Short Label hHNRNPK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61978 (HNRNPK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
T3 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
K21 Acetylation PhosphoSitePlus
R22 Methylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K34 Methylation PhosphoSitePlus
K34 Sumoylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S36 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T39 Phosphorylation PhosphoSitePlus
R46 Methylation PhosphoSitePlus
K52 Sumoylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K60 Sumoylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 18698806, 12052863
S75 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S77 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S116 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 20960454, 17287340, 24236111, ...15302935, 18669648, 24275569, 28423622
T118 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T120 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 28423622
S121 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
K139 Methylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
R148 Methylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K163 Sumoylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
C184 S-Nitrosylation dbSNO 19483679
C185 S-Nitrosylation dbSNO 19483679, 2212679, 22126794
S188 Phosphorylation PhosphoSitePlus
R191 Methylation PhosphoSitePlus
K198 Methylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
R201 Methylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus   UniProt 21406692
S216 Phosphorylation P24941 (CDK2) , P53779 (MAPK10) , P45983 (MAPK8) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 11259409, 23186163, ...16964243, 18847512, 25410660, 18234856, 27851963, 17081983, 18669648, 19690332, 20068231, 20865152
K219 Acetylation PhosphoSitePlus
K219 Sumoylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
Y225 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 12052863
Y230 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 12052863
Y234 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 12052863
Y236 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 12052863
R246 Methylation PhosphoSitePlus
R247 Methylation PhosphoSitePlus
R249 Methylation PhosphoSitePlus
R256 Methylation PhosphoSitePlus
R258 Methylation PhosphoSitePlus
R263 Methylation PhosphoSitePlus
R268 Methylation PhosphoSitePlus
R271 Methylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
R277 Methylation PhosphoSitePlus
R278 Methylation PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
S284 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20960454, 26638989, 17081983, ...16083285, 17287340, 16964243, 16564677, 25410660, 15302935, 21406692, 11231586, 26804170, 18669648, 11259409, 24275569, 23186163, 30123777, 10329716, 20068231, 20865152
R286 Methylation PhosphoSitePlus
R287 Methylation PhosphoSitePlus
R296 Methylation PhosphoSitePlus
R299 Methylation PhosphoSitePlus
S302 Phosphorylation Q05655 (PRKCD) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 25104022, 10329716, 31110205
R303 Methylation PhosphoSitePlus
R305 Methylation PhosphoSitePlus
R316 Methylation PhosphoSitePlus   UniProt 24129315
Y323 Phosphorylation PhosphoSitePlus
R325 Methylation PhosphoSitePlus
R326 Methylation PhosphoSitePlus
R328 Methylation PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
S353 Phosphorylation P53779 (MAPK10) , P45983 (MAPK8) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26638989, 11259409, 11231586, ...30123777, 20865152
Y361 Phosphorylation PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus
Y371 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
Y373 Phosphorylation PhosphoSitePlus
R377 Methylation PhosphoSitePlus
S379 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 21406692, 23186163, 16964243, ...31110205, 26782714, 20068231, 21821029
Y380 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 12052863, 19690332
T389 Phosphorylation PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
K405 Sumoylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus   UniProt 23186163
K422 Acetylation PhosphoSitePlus
K422 Sumoylation PRO   PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
R433 Methylation PhosphoSitePlus
T436 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
Y458 Phosphorylation P12931 (SRC) PhosphoSitePlus 16854432, 24642125
K461 Acetylation PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 15302935, 18452278
S36 Phosphorylation HPRD 17081983
Y72 Phosphorylation P12931 (SRC) HPRD 12052863
S116 Phosphorylation HPRD 18691976, 17287340, 15302935, ...19664995, 18452278, 18669648, 20068231
T118 Phosphorylation HPRD 18669648, 19415658, 18452278
T120 Phosphorylation HPRD 18669648, 17081983
S127 Phosphorylation HPRD 17081983
Y135 Phosphorylation HPRD 17081983
S214 Phosphorylation HPRD 18691976, 17081983, 20230923, ...19664995, 18452278, 19415658, 20068231, 17924679
S216 Phosphorylation P53779 (MAPK10) HPRD 19413330, 18691976, 18212344, ...20230923, 16964243, 18767875, 19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 19415658, 20068231, 17924679
Y225 Phosphorylation P12931 (SRC) HPRD 12052863
Y230 Phosphorylation P12931 (SRC) HPRD 12052863
Y234 Phosphorylation P12931 (SRC) HPRD 12052863
Y236 Phosphorylation P12931 (SRC) HPRD 12052863
Y280 Phosphorylation HPRD 20068231
S284 Phosphorylation P53779 (MAPK10) HPRD 19413330, 18691976, 17287340, ...16964243, 18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 20166139, 19415658, 20068231
S302 Phosphorylation Q05655 (PRKCD) HPRD 10329716
S353 Phosphorylation P53779 (MAPK10) HPRD 11259409, 11231586
S379 Phosphorylation HPRD 18691976, 16964243, 20230923, ...20058876, 19664995, 18452278, 19651622, 20166139, 20068231, 17924679
Y380 Phosphorylation HPRD 17322306, 18669648, 19415658, ...18452278
S401 Phosphorylation HPRD 20068231
S417 Phosphorylation HPRD 20230923
S420 Phosphorylation HPRD 20230923
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 15302935, 18452278
S36 Phosphorylation HPRD 17081983
K60 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation P12931 (SRC) HPRD 12052863
S116 Phosphorylation HPRD   PhosphoSitePlus 18691976, 17287340, 15302935, ...19664995, 18452278, 18669648, 20068231
T118 Phosphorylation HPRD 18669648, 19415658, 18452278
T120 Phosphorylation HPRD 18669648, 17081983
S127 Phosphorylation HPRD 17081983
Y135 Phosphorylation HPRD 17081983
S214 Phosphorylation HPRD 18691976, 17081983, 20230923, ...19664995, 18452278, 19415658, 20068231, 17924679
S216 Phosphorylation P53779 (MAPK10) HPRD 19413330, 18691976, 18212344, ...20230923, 16964243, 18767875, 19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 19415658, 20068231, 17924679
K219 Acetylation PhosphoSitePlus
Y225 Phosphorylation P12931 (SRC) HPRD 12052863
Y230 Phosphorylation P12931 (SRC) HPRD 12052863
Y234 Phosphorylation P12931 (SRC) HPRD 12052863
Y236 Phosphorylation P12931 (SRC) HPRD 12052863
Y280 Phosphorylation HPRD 20068231
S284 Phosphorylation P53779 (MAPK10) HPRD   PhosphoSitePlus 19413330, 17287340, 16964243, ...18691976, 18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 20166139, 19415658, 20068231
S302 Phosphorylation Q05655 (PRKCD) HPRD 10329716
S353 Phosphorylation P53779 (MAPK10) HPRD 11259409, 11231586
S379 Phosphorylation HPRD 18691976, 16964243, 20230923, ...20058876, 19664995, 18452278, 19651622, 20166139, 20068231, 17924679
Y380 Phosphorylation HPRD 17322306, 18669648, 19415658, ...18452278
S401 Phosphorylation HPRD 20068231
K405 Ubiquitination PhosphoSitePlus
S417 Phosphorylation HPRD 20230923
S420 Phosphorylation HPRD 20230923
Y449 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K456 Sumoylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
Y458 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K115 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047887 (hHNRNPK/Sumo:1) suK422 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49841 (GSK3B) S9 P61978 (HNRNPK) increased_association eFIP 26638989


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K34 N34 Biomuta DOID:363 / uterine cancer [ tcga ]
S36 Y36 Biomuta DOID:363 / uterine cancer [ tcga ]
R46 H46 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K52 M52 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K66 N66 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S75 T75 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T118 N118 Biomuta DOID:3571 / liver cancer [ icgc ]
T118 A118 Biomuta DOID:1324 / lung cancer [ cosmic ]
C185 F185 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
K198 R198 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y234 * Biomuta DOID:1793 / pancreatic cancer [ icgc ]
R246 P246 Biomuta DOID:10534 / stomach cancer [ tcga ]
R246 C246 Biomuta DOID:363 / uterine cancer [ tcga ]
R247 H247 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ tcga ]
R249 C249 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R256 W256 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R258 T258 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R268 L268 Biomuta DOID:5041 / esophageal cancer [ icgc ]
R268 W268 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R271 C271 Biomuta DOID:3070 / malignant glioma [ icgc ]
R271 H271 Biomuta DOID:363 / uterine cancer [ tcga ]
R287 * Biomuta DOID:1612 / breast cancer [ tcga ]
R305 W305 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
R305 Q305 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ cosmic ] DOID:3070 / malignant glioma [ tcga ]
R328 I328 Biomuta DOID:363 / uterine cancer [ tcga ]
Y369 H369 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S372 A372 Biomuta DOID:3070 / malignant glioma [ cosmic ]
R377 S377 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R377 C377 Biomuta DOID:363 / uterine cancer [ tcga ]
K405 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
R433 W433 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R433 Q433 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R433 L433 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]