iPTMnet Report for P61964 (WDR5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61964 / WDR5_HUMAN
Protein Name WD repeat-containing protein 5
Gene Name Name: WDR5
Synonyms:BIG3;
Organism Homo sapiens (Human)

PRO ID PR:P61964
DAG View
PRO Name WD repeat-containing protein 5 (human)
Definition A WD repeat-containing protein 5 that is encoded in the genome of human.
Short Label hWDR5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61964 (WDR5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
T18 Phosphorylation PhosphoSitePlus
S21 O-Glycosylation GlyGen 20305658, 33214551, 34019948, ...21740066, 35254053
K27 Ubiquitination PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K38 Methylation PhosphoSitePlus
K46 Sumoylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus   RLIMS-P 27661449
S54 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
T82 O-Glycosylation GlyGen 20305658, 33214551, 34019948, ...21740066, 35254053
K112 Acetylation PhosphoSitePlus   UniProt 19608861
K120 Ubiquitination PhosphoSitePlus
C121 Methylation IEDB 31844290
Y131 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K207 Methylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
S267 Phosphorylation HPRD   PhosphoSitePlus 17924679
T290 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K325 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 P2 Biomuta DOID:3571 / liver cancer [ cosmic ]
S21 L21 Biomuta DOID:3571 / liver cancer [ cosmic ]
K27 R27 Biomuta DOID:184 / bone cancer [ cosmic ]
S54 N54 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K78 N78 Biomuta DOID:363 / uterine cancer [ icgc ]
T290 M290 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]