Protein Information

Cytoscape View


UniProt AC / UniProt ID P61916 / NPC2_HUMAN
Protein Name NPC intracellular cholesterol transporter 2 precursor
Gene Name Name: NPC2
Synonyms:HE1;
Organism Homo sapiens (Human)

PRO ID PR:P61916
DAG View
PRO Name NPC intracellular cholesterol transporter 2 (human)
Definition An NPC intracellular cholesterol transporter 2 that is encoded in the genome of human.
Short Label hNPC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61916 (NPC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
N58 N-Glycosylation GlyGen   UniProt 17018531, 15542393, 23090970, ...27551080, 29741879
K94 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
N135 N-Glycosylation GlyGen   UniProt 17018531, 15542393, 27551080, ...19159218


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 F29 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K94 M94 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y107 H107 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K112 N112 Biomuta DOID:263 / kidney cancer [ cosmic ]