iPTMnet Report for P61916 (NPC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61916 / NPC2_HUMAN
Protein Name NPC intracellular cholesterol transporter 2 precursor
Gene Name Name: NPC2
Synonyms:HE1;
Organism Homo sapiens (Human)

PRO ID PR:P61916
DAG View
PRO Name NPC intracellular cholesterol transporter 2 (human)
Definition An NPC intracellular cholesterol transporter 2 that is encoded in the genome of human.
Short Label hNPC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61916 (NPC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
N58 N-Glycosylation GlyGen   UniProt 15542393, 17018531, 23090970, ...27551080, 29741879
K94 Acetylation PhosphoSitePlus
C99 Methylation IEDB 31844290
K105 Ubiquitination PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
N135 N-Glycosylation GlyGen   UniProt 17018531, 15542393, 27551080, ...19159218


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 F29 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K94 M94 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y107 H107 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K112 N112 Biomuta DOID:263 / kidney cancer [ cosmic ]