Protein Information

Cytoscape View


UniProt AC / UniProt ID P61764 / STXB1_HUMAN
Protein Name Syntaxin-binding protein 1
Gene Name Name: STXBP1
Synonyms:UNC18A;
Organism Homo sapiens (Human)

PRO ID PR:P61764
DAG View
PRO Name syntaxin-binding protein 1 (human)
Definition A syntaxin-binding protein 1 that is encoded in the genome of human.
Short Label hSTXBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61764 (STXBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus   RLIMS-P 15489225, 12950453
K314 Ubiquitination PhosphoSitePlus
K321 Methylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
Y337 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
T479 Phosphorylation Q13627 (DYRK1A) neXtProt   RLIMS-P 22765017
T489 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus   RLIMS-P 15489225
K587 Ubiquitination PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
S594 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S306 Phosphorylation P05129 (PRKCG) , P17252 (PRKCA) , P05771 (PRKCB) HPRD 12519779
S313 Phosphorylation P05771 (PRKCB) , P05129 (PRKCG) , P17252 (PRKCA) HPRD 12519779
S594 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S306 Phosphorylation P05771 (PRKCB) , P05129 (PRKCG) , P17252 (PRKCA) HPRD 12519779, 8631738
S313 Phosphorylation P05771 (PRKCB) , P05129 (PRKCG) , P17252 (PRKCA) HPRD 12950453, 12519779, 8631738
S590 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 C70 Biomuta DOID:1324 / lung cancer [ cosmic ]
K92 N92 Biomuta DOID:3571 / liver cancer [ icgc ]
K92 R92 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y145 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K196 R196 Biomuta DOID:10283 / prostate cancer [ clinvar, cosmic ]
K294 N294 Biomuta DOID:3571 / liver cancer [ icgc ]
S313 C313 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K314 N314 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S454 F454 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T455 M455 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S593 N593 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S594 G594 Biomuta DOID:9256 / colorectal cancer [ tcga ]