iPTMnet Report for P61619 (SEC61A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61619 / S61A1_HUMAN
Protein Name Protein transport protein Sec61 subunit alpha isoform 1
Gene Name Name: SEC61A1
Synonyms:SEC61A;
Organism Homo sapiens (Human)

PRO ID PR:P61619
DAG View
PRO Name protein transport protein Sec61 subunit alpha isoform 1 (human)
Definition A protein transport protein Sec61 subunit alpha isoform 1 that is encoded in the genome of human.
Short Label hSEC61A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61619 (SEC61A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
C46 Methylation IEDB 31844290
T75 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
R273 Methylation PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
C342 Methylation IEDB 31844290
Y344 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K4 N4 Biomuta DOID:363 / uterine cancer [ icgc ]
T86 M86 Biomuta DOID:3571 / liver cancer [ cosmic ]
T105 S105 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T105 A105 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S197 N197 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R273 H273 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S346 P346 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S350 Y350 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S350 F350 Biomuta DOID:4159 / skin cancer [ cosmic ]
K395 N395 Biomuta DOID:1324 / lung cancer [ cosmic ]