iPTMnet Report for P61586 (RHOA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61586 / RHOA_HUMAN
Protein Name Transforming protein RhoA precursor
Gene Name Name: RHOA
Synonyms:ARH12,ARHA,RHO12;
Organism Homo sapiens (Human)

PRO ID PR:P61586
DAG View
PRO Name transforming protein RhoA (human)
Definition A GTP-binding protein RhoA that is encoded in the genome of human.
Short Label hRHOA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61586 (RHOA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
T19 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K27 Sumoylation PhosphoSitePlus
Y34 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 23027962, 33388549
T37 O-Glycosylation UniProt 7775453, 24905543, 7777059, ...8810274
Y42 Phosphorylation PhosphoSitePlus   RLIMS-P 28712859, 33388549
T60 Phosphorylation PhosphoSitePlus
Y66 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 23027962, 33388549
S73 Phosphorylation RLIMS-P 29279389
S88 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 26816343
T100 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 26816343
K104 Ubiquitination PhosphoSitePlus
C107 S-Nitrosylation dbSNO 26338901
K118 Acetylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K119 Methylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus   RLIMS-P 24191200
R128 Methylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus   UniProt 23871831
K140 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
C159 S-Nitrosylation dbSNO 2212679, 22126794
S160 Phosphorylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S188 Phosphorylation Q9H2G2 (SLK) , P17612 (PRKACA) , Q13976 (PRKG1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 25734240, 15326221, 21304528, ...32692911, 19737918, 24549567, 15572519, 28509344, 11162591, 29765417, 21572420, 22504159, 33817200, 27355867, 9712882, 12119292, 24191200, 28740547, 16969490, 24100445, 29435180, 8599934, 28004812, 18953413, 28278256, 31209254, 12654918, 18420945, 33195261, 23012358, 24917553, 27270401, 16246900, 20591975


P61586 (RHOA) as PTM Enzyme



Substrate Site Score Source PMID
P15311 (EZR) T567 Signor 35267019
P26038 (MSN) T558 Signor 35267019
P35241 (RDX) T564 Signor 35267019


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60716 (CTNND1) Y228 P61586 (RHOA) increased_association eFIP 32063714
Phosphorylation P52565 (ARHGDIA) Y156 P61586 (RHOA) increased_association eFIP 29377108
Phosphorylation P52565 (ARHGDIA) S96 P61586 (RHOA) unknown eFIP 23776598
Phosphorylation P61586 (RHOA) S188 P52565 (ARHGDIA) increased_association eFIP 23776598
Phosphorylation P61586 (RHOA) Y42 P52565 (ARHGDIA) increased_association eFIP 29377108
Phosphorylation P61586 (RHOA) S188 P62826 (RAN) unknown eFIP 31209254
Phosphorylation P61586 (RHOA) S188 O60610 (DIAPH1) increased_association eFIP 20591975
Phosphorylation P61586 (RHOA) Y42 P35222 (CTNNB1) unknown eFIP 33388549